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Fig. 5 | Intensive Care Medicine Experimental

Fig. 5

From: Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation

Fig. 5

Induction of autophagy restores the expression of osteoblast differentiation markers in trabecular bone of critically ill rabbits. The expression of RUNX2 (a), OSX (b), and COLA1 (c) was significantly decreased in the critically ill rabbits as compared to healthy controls (p < 0.05; n = 6 per group). (d) No change in the RANKL/OPG ratio was observed critically ill rabbits, however a trend for increased CD16b (e) and DAP12 (f) expression was observed (n = 6 per group)

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