Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI

Bergan, Harald Arne; Halvorsen, Per Steinar; Skulstad, Helge; Edvardsen, Thor; Fosse, Erik; Bugge, Jan Frederik

doi:10.1186/s40635-015-0061-2

Intensive Care Medicine Experimental

Table 3 Haemodynamic measurements and blood gas values

From: Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI

A. Pulmonary artery catheter measurements and MAP
Variable	Baseline	Post-arrest	MD (95 % CI)	p value
HR_PA beats/min	86 ± 22	147 ± 28	61 ( 37 86)	p < 0.001
MAP mmHg	84.3 ± 13.1	74.6 ± 16.8	−9.6 (−27.0 7.8)	p = 0.23
CO_PA l/min	4.5 ± 0.6	3.8 ± 0.4	−0.72 (−1.5–0.08)	p = 0.07
SV_PA ml	53 ± 6	26 ± 3	−27 (−33–22)	p < 0.001
MPAP mmHg	17.8 ± 3.6	23.6 ± 4.3	5.9 ( 3.4 8.4)	p < 0.001
CVP mmHg	6.3 ± 2.6	6.3 ± 3.2	0.0 (−2.0 2.0)	p = 1.0
Wedge mmHg	8.7 ± 3.7	8.5 ± 3.4	−0.2 (−3.4 3.1)	p = 0.89
SVR dyne•s/cm⁻⁵	1390 ± 232	1438 ± 288	48 (−114 209)	p = 0.51
B. Left ventricle pressure transducer measurements
Variable	Baseline	Post-arrest	MD (95 % CI)	p value
LVP_max mmHg	99.2 ± 7.1	91.4 ± 14.4	−7.9 (−23.4 7.6)	p = 0.27
EDP mmHg	15.5 ± 4.0	14.7 ± 2.5	−0.8 (−5.4 3.9)	p = 0.71
dP/dt _max mmHg/sec	1440 ± 209.5	2034 ± 549.4	594.1 (15.3 1173)	p = 0.046
dP/dt_min mmHg/sec	−2086 ± 285	−1715 ± 419	371 ( −185 926)	p = 0.16
tau msec	32.8 ± 3.0	33.5 ± 7.3	0.68 (−5.7 7.1)	p = 0.68
Ea mmHg/ml	1.04 ± 0.21	1.67 ± 0.47	0.63 (0.21 1.06)	p = 0.009
DD msec	440 ± 89	190 ± 40	−250 (−336–165)	p < 0.001
SD msec	328 ± 19	220 ± 19	−109 ( −133–84)	p < 0.001
IVC msec	50 ± 7	42 ± 6	−9 (−14–3)	p = 0.007
C. Blood gas analyses
Variable	Baseline	Post-arrest	MD (95 % CI)	p value
Haemoglobin g/dl	8.4 ± 0.7	8.2 ± 0.8	−0.24 (−0.49 0.02)	p = 0.06
PaO₂ kPa	22.6 ± 2.1	20.1 ± 3.5	−2.5 (−4.7–0.34)	p = 0.03
PaCO₂ kPa	5.2 ± 0.4	5.3 ± 0.3	0.14 (−0.29 0.57)	p = 0.46
pH	7.50 ± 0.03	7.47 ± 0.04	−0.03 (−0.07 0.01)	p = 0.08
Base excess mmol/l	6.63 ± 1.25	4.73 ± 1.79	−1.9 (−3.02–0.78)	p = 0.005
Lactate mmol/l	0.88 ± 0.21	1.34 ± 0.54	0.46 (−0.03 0.95)	p = 0.06
Ca²⁺ mmol/l	1.29 ± 0.07	1.26 ± 0.07	−0.025 (−0.08 0.03)	p = 0.32
SvO₂ %	69.4 ± 13.1	44.0 ± 7.9	−25.4 (−36.4–14.4)	p < 0.001
DO₂ ml/min	572 ± 124	499 ± 119	−74 (−228 79)	p = 0.29
VO₂ ml/min	164 ± 49	273 ± 46	109 (57 160)	p = 0.002

HR _PA , CO _PA and SV _PA pulmonary artery catheter assessments of heart rate, cardiac output and stroke volume, MAP mean aortic pressure, CVP central venous pressure, Wedge pulmonary arterial wedge pressure, SVR systemic vascular resistance, LVP _max systolic left ventricular pressure maximum, EDP end-diastolic pressure, dP/dt _max and dP/dt _min maximum and minimum LVP time derivates, tau isovolumetric relaxation constant, Ea arterial elastance, DD diastolic duration, SD systolic duration, IVC isovolumetric contraction time, S _V O ₂ mixed venous oxygen saturation, D _O2 oxygen delivery, V _O2 oxygen consumption
Values are expressed as mean ± standard deviation. MD mean difference, CI confidence interval, significance level p ≤ 0.05

Back to article page