Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis

Intensive Care Medicine Experimental

Table 2 Test characteristics of CPIS and biomarkers

Time point	CPIS	Biomarkers	Combined	NRI	IDI
Time point	(ROC-AUC)	(ROC-AUC)	(ROC-AUC)	NRI	IDI
Moment of diagnosis	0.94	0.96	1.0	Inf	0.37; p = 0.001
Three days before	0.59	0.79	0.74	0.8; p = 0.046	0.19; p = 0.039
Slope	0.95	0.77	0.97	0.4; p = 0.36	0.03; p = 0.38

ROC-AUC area under the receiver operating characteristic curve, NRI net reclassification index, IDI integrated discrimination index