Fig. 6

Effect of the drugs administered to the mice immediately after being exposed twice to LISW at 1.4 J/cm² on systolic blood pressure (sBP), heart rate (HR), peripheral oxyhemoglobin saturation (SpO₂), and the shock index. a HR was measured immediately before (baseline) and at 5 and 10 min after LISW. NA, DOB, and NS groups were exposed twice to LISW and then received 20 μg of noradrenaline, 60 μg of dobutamine, and 0.1 mL of normal saline, respectively. p < 0.01 interaction by repeated measures ANOVA, **p < 0.01; *p < 0.05 for significance between two groups determined according to Scheffe’s F test. #p < 0.05; significance between each value in NS group, baseline, and 5 min in NA group, and corresponding vs. 10 min-value in DOB group (Wilcoxon signed-rank test). ††p < 0.01; significance between baseline and 10 min in NA group, baseline, and 5 min in DOB group (paired t test). The data are shown as the mean ± standard error. b sBP was measured before (baseline) and at 5 and 10 min after LISW. NA, DOB, and NS groups were exposed twice to LISW and then received 20 μg of noradrenaline, 60 μg of dobutamine, and 0.1 mL of normal saline, respectively. p < 0.05 interaction by repeated measures ANOVA, *p < 0.05 for significance between two groups determined according to Scheffe’s F test. #p < 0.05; significance corresponding vs. baseline values in NS group (Wilcoxon signed-rank test). ††p < 0.01; significance corresponding vs. baseline value in DOB group (paired t test). c SpO₂ was measured immediately before (baseline) and at 5 and 10 min after LISW. #p < 0.01 vs. corresponding baseline values in all groups (paired t test). d The shock index was measured immediately at baseline and 5 and 10 min after LISW. There were no significant differences between the groups or based on time