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Table 2 Gas exchange and respiratory mechanics

From: Lung anatomy, energy load, and ventilator-induced lung injury

 

End-inspiratory volumes/inspiratory capacity

 

Below

Within

Above

 

First

Last

P

First

Last

P

First

Last

P

No.

29

38

9

Lung weight (g)

308 [287–350]

253 [220–275]

0.057

317 [294–349]

483 [301–655]

<0.001

325 [287–340]

242 [220–430]

0.820

PaCO2 (mmHg)

38.0 [34.0–43.0]

30.0 [26.0–40.0]

0.005

39.5 [36.0–43.0]

46.5 [39.0–56.0]

0.002

35.8 [34–41.7]

40.8 [35.0–48.8]

0.056

PaO2 (mmHg)

234.5 ± 46.0

202.6 ± 58.4

0.020

229.0 ± 40.3

133.3 ± 75.1

<0.001

243.7 ± 27.8

178.8 ± 83.9

0.061

Ers (cmH2O/L

32.9 [29.8–38.8]

43.7 [35.6–53.2]

<0.001

33.3 [29.4–45.3]

51.0 [42.8–61.6]

0.005

42.3 [34.9–47.4]

52.9 [41.8–56.8]

0.292

Ecw (cmH2O/L)

17.9 [14.5–20.2]

15.9 [14.8–19.8]

0.270

16.4 [13.5–19.0]

15.9 [14.3–19.4]

1.00

14.2 [13.0–19.3]

14.1 [13.7–17.8]

0.808

El (cmH2O/L)

15.4 [12.3–22.3]

27.4 [20.2–39.3]

<0.001

19.2 [14.0–30.9]

33.0 [25.9–43.5]

0.018

28.1 [27.6–29.8]

42.7 [35.6–44.6]

0.159

IL-6 (pg/mL)

10.0 [10.0–54.0]

10.0 [10.0–80.0]

1.00

16.5 [10.0–39.0]

185.5 [12.0–449.0]

<0.001

10.4 [5.3–14.3]

14.3 [5.2–694.0]

0.500

  1. Mean ± standard deviation or median (interquartile range) of gas exchange and respiratory mechanics at the beginning (FIRST) and end (LAST) of the experiments. Pigs were grouped according to end-inspiratory volume as lower (BELOW), within (WITHIN), or higher (ABOVE) than normal inspiratory capacity. P refers to paired t test or Wilcoxon’s Signed Rank Test, as appropriate. Lung weight (available data, 26 below, 38 within, 9 above)
  2. PaCO 2 indicates partial pressure of carbon dioxide (29 below, 38 within, 6 above), PaO 2 indicates partial pressure of oxygen (29 below, 38 within, 6 above), Ers indicates respiratory system elastance (26 below, 37 within, 6 above), Ecw indicates chest wall elastance (24 below, 31 within, 5 above), El indicates lung elastance (24 below, 31 within, 5 above), IL-6 indicates serum interleukin 6 (17 below, 28 within, 3 above)