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Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

Fig. 1

In vivo effects of unfractionated heparin, low-molecular-weight heparin, and argatroban. Significant decreases of the fibrin/fibrinogen degradation products (FDP) were observed in all of the treatment groups as compared to the level in the histone H3-treated control. Similar effects were observed in the high-dose and low-dose groups of each agent. The animals given with histone H3 and saline were served as control. Blood samples were obtained 6 h after the administration of histone H3. Unfractionated heparin (UFH), low dose 350 U/kg, high dose 700 U/kg; low-molecular-weight heparin (LMWH), low dose 2.0 mg/kg, high dose 4.0 mg/kg; argatroban, low dose 3.6 mg/kg, high dose 7.2 mg/kg. **p < 0.01 (n = 6 in each subgroup)

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