Skip to main content
Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

Fig. 2

In vivo effects of unfractionated heparin, low-molecular-weight heparin, and argatroban. Decreases of the white blood cell (WBC) and platelet counts by histone H3 were significantly suppressed by all of the anticoagulants. Increased alanine aminotransferase (ALT) and blood urea nitrogen (BUN) levels were significantly suppressed by unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH); however, no such effect was observed with argatroban. The animals given with histone H3 and saline were served as control. Blood samples were obtained 6 h after the administration of histone H3. UFH, low dose 350 U/kg, high dose 700 U/kg; LMWH, low dose 2.0 mg/kg, high dose 4.0 mg/kg; argatroban, low dose 3.6 mg/kg, high dose 7.2 mg/kg. **p < 0.01 (n = 6 in each subgroup)

Back to article page