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Table 1 Comparison of survival rates in a rat model of histone H3 administration

From: Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

Group Histone H3 dose (mg/kg)
25 50 100
No treatment 1/6 (17 %) 0/6 (0 %) 0/6 (0 %)
UFH high-dose 6/6* (100 %) 6/6** (100 %) 4/6 (67 %)
LMWH high-dose 6/6* (100 %) 5/6* (83 %) 4/6 (67 %)
Argatroban high-dose 1/6 (17 %) 1/6 (17 %) 0/6 (0 %)
  1. *p < 0.05; **p < 0.01 compared with no treatment group