Kinetics of arterial carbon dioxide during veno-venous extracorporeal membrane oxygenation support in an apnoeic porcine model

Mendes, Pedro Vitale; Park, Marcelo; Maciel, Alexandre Toledo; e Silva, Débora Prudêncio; Friedrich, Natalia; Barbosa, Edzangela Vasconcelos Santos; Hirota, Adriana Sayuri; Schettino, Guilherme Pinto Paula; Azevedo, Luciano Cesar Pontes; Costa, Eduardo Leite Vieira

doi:10.1186/s40635-015-0074-x

Intensive Care Medicine Experimental

Table 1 Physiological variables after 50 min of sweep or blood flow modifications

From: Kinetics of arterial carbon dioxide during veno-venous extracorporeal membrane oxygenation support in an apnoeic porcine model

	Blood flow = 1500 mL/min			Blood flow = 3500 mL/min
Variable	Sweep flow 3.0 L/min	Sweep flow 1.5 L/min	Sweep flow 10 L/min	Sweep flow 2.0 L/min	Sweep flow 3.5 L/min	Sweep flow 7.0 L/min	Sweep flow 12 L/min	P value*
pH	7.21 [7.17,7.32]	7.03 [7.01,7.16]	7.26 [7.19,7.38]	7.08 [7.04,7.22]	7.16 [7.14,7.29]	7.31 [7.27,7.40]	7.43 [7.37,7.49]	<0.001
SBE (mmol/L)	0.9 [0.0,1.4]	−5.2 [−9.1,−1.2]	0.3 [−2.2,2.5]	−0.3 [−1.7,0.4]	1.2 [−1.2,2.0]	4.3 [2.9,4.9]	4.8 [4.7,6.3]	<0.001
SatO₂ (%)	87 [81,98]	85 [75,96]	97 [80,99]	99 [91,100]	99 [91,100]	99 [96,99]	99 [98,100]	0.003
CaO₂ (mL O₂/100 mL of blood)	17 [14,17]	16 [13,18]	17 [14,18]	15 [14,18]	17 [15,18]	15 [15,19]	15 [14,18]	0.764
CaCO₂ (mL CO₂/100 mL of blood)	58 [57,64]	65 [54,66]	64 [58,66]	67 [63,74]	64 [61,64]	65 [63,65]	63 [63,69]	0.179
Lactate (mmol/L)	1.6 [1.3,2.2]	2.7 [1.7,3.6]	1.9 [1.7,4.3]	2.6 [1.1,3.4]	1.6 [1.6,3.2]	1.0 [1.0,1.8]	1.7 [0.8,2.1]	0.031
Hemoglobin (g/dL)	13 [12,14]	14 [13,14]	13 [12,13]	12 [11,13]	12 [12,13]	12 [11,13]	11 [10,13]	0.003
Chloride (mmol/L)	104 [103,104]	103 [103,104]	103 [103,104]	103 [103,104]	103 [103,104]	103 [102,105]	103 [103,104]	0.880
Sodium (mmol/L)	140 [138,143]	140 [139,142]	140 [137,141]	141 [138,141]	139 [138,142]	137 [137,139]	139 [136,139]	0.007
Calcium (mmol/L)	1.4 [1.4,1.4]	1.4 [1.3,1.4]	1.3 [1.3,1.3]	1.4 [1.3,1.4]	1.3 [1.3,1.4]	1.3 [1.3,1.4]	1.3 [1.3,1.3]	0.007
Glucose (mg/dL)	112 [103,131]	129 [116,214]	135 [115,158]	137 [124,138]	116 [112,127]	126 [121,128]	119 [118,121]	0.007
Pulmonary shunt (%)	47 [26,54]	60 [33,67]	45 [29,66]	67 [55,72]	54 [47,55]	56 [31,59]	50 [44,56]	0.115
Temperature (°C)	37.2 [36.8,38.5]	37.5 [36.6,38.4]	37.5 [36.4,38.2]	38.0 [37.0,38.1]	37.7 [36.9,38.2]	37.5 [37.0,38.2]	37.5 [37.0,38.2]	0.534
O₂ transfer (mL/min)	116 [108,134]	115 [103,128]	133 [98,190]	246 [211,246]	201 [197,222]	206 [200,217]	207 [181,237]	<0.001
CO₂ transfer (mL/min)	209 [204,283]	185 [178,204]	319 [275,377]	255 [223,275]	259 [238,320]	365 [294,386]	383 [296,400]	<0.001
Rotations (RPM)	2075 [1930,2175]	2075 [1980,2175]	2075 [1980,2175]	3485 [3380,3780]	3485 [3380,3780]	3485 [3380,3725]	3485 [3380,3725]	<0.001
CO (L/min)	6.5 [6.4,6.9]	6.3 [4.0,6.7]	7.7 [3.6,9.4]	7.3 [4.3,9.3]	9.0 [4.4,9.1]	7.6 [4.8,8.2]	6.3 [4.8,7.9]	0.834
Heart rate (bpm)	134 [124,145]	133 [95,137]	135 [123,147]	128 [124,149]	137 [131,160]	121 [121,153]	128 [123,161]	0.867
ABPm (mmHg)	126 [106,126]	106 [100,125]	101 [91,112]	98 [92,105]	103 [94,114]	113 [112,122]	122 [119,123]	0.154
PAPm (mmHg)	54 [41,59]	46 [42,47]	36 [32,46]	47 [34,48]	40 [31,47]	42 [35,45]	39 [33,44]	0.248
CVP (mmHg)	6 [5,13]	6 [4,16]	5 [4,13]	5 [3,15]	5 [4,14]	5 [4,11]	5 [4,11]	0.299
PAOP (mmHg)	11 [10,12]	8 [8,11]	8 [7,11]	7 [5,9]	8 [7,8]	8 [6,16]	8 [7,17]	0.715

Post hoc analyses were not done due to the high spectrum of comparisons (varying through the blood flow and sweep gas flows domains)
SBE standard base excess, CaO ₂ arterial content of oxygen, CaCO ₂ arterial content of CO₂, CO cardiac output, ABPm mean arterial blood pressure, PAPm mean pulmonary arterial blood pressure, CVP central venous pressure, PAOP pulmonary artery occlusion pressure
*The P values were obtained through the Friedman’s test

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