Figure 1

a Survival in Drosophila melanogaster after septic injury with Staphylococcus aureus. Flies were infected using needle pricking assay with S. aureus; survival was assessed by observing flies every hour for the first 72 h from 8 a.m. until 11 p.m. Of the infected without treatment flies, 75 % died by the 28th hour after infection; infected with antibiotics group received oral linezolid for 18 h and showed improved survival without any death due to infection in the first 72 h after infection. Sham group pricked with sterile needle showed no death due to pricking-related trauma. We used 25 flies in each group; survival experiment was repeated three times for the Kaplan-Meyer survival analysis (*p < 0.05). b Geotaxis in Drosophila melanogaster after septic injury with Staphylococcus aureus. Each geotaxis experiment was performed 1 h before the needle pricking (0-h baseline) and at 18, 48, 72, and 96 h after needle pricking. Geotaxis in sham flies was significantly lower at 72 h compared to its baseline. Infected with antibiotics group showed significantly lower geotaxis compared to baseline at 18, 48, and 72 h. While there was significant difference in geotaxis between sham and infected with antibiotics groups at 18 and 48 h, this difference was lost by 72 h. Geotaxis of unmanipulated healthy flies remained at the baseline through experiment. We repeated each geotaxis experiment six times (*p < 0.05)