Intensive Care Medicine Experimental

Table 2 Production of ROS, NO, IL-6, and TNF-α by monocytes of septic patients and healthy volunteers

From: Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines

	Septic patients			Healthy volunteers
	Median	Percentiles 25–75		Median	Percentiles 25–75
ROS (GMFI)							P ^a
Control	2459	1735	4546	1005	761	1487	<0.001
LPS	3387	2049	6205	1177	829	1503	<0.001
P. aeruginosa	3972	2257	6514	1372	928	1560	<0.001
S. aureus	9296	5573	18507	2479	1749	3275	<0.001
NO (GMFI)
Control	479	362	621	209	176	305	<0.001
LPS	572	448	792	284	243	389	<0.001
P. aeruginosa	917	631	1493	517	422	667	<0.001
S. aureus	840	617	1103	372	309	663	<0.001
IL-6 (%)
LPS	10.9	4.9	41.2	70.8	60.2	77.5	<0.001
P. aeruginosa	24.1	4.9	51.8	70.4	54.1	78.1	<0.001
S. aureus	9 · 6	4.1	25.1	24.8	18.9	41.9	0.002
TNF-α (%)
LPS	18.6	6.5	36.2	66.7	47.8	72.1	<0.001
P. aeruginosa	33.4	17.5	56.8	70.7	61.4	86.8	<0.001
S. aureus	19.6	9.3	42.4	33.6	26.5	43.9	0.023

Values for ROS and NO are shown as geometric mean fluorescence intensities (GMFIs) of DCFH and DAF, respectively. Cytokine values are shown as percentages of cells producing IL-6 and TNF-α
^aMann-Whitney U test

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