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Intensive Care Medicine Experimental

Table 2 Heparan sulphate and syndecan-1 concentrations and total circulating quantity at the end of the experiment

From: Effects of fresh frozen plasma, Ringer’s acetate and albumin on plasma volume and on circulating glycocalyx components following haemorrhagic shock in rats

  

Concentration

  

Quantity

 
 

Baseline

After haemorrhage

Resuscitated

 

Resuscitated

 

HS (μg/ml)

   

HS (μg/kg)

FFP

22 ± 20

85 ± 37

53 ± 21

*#

2879 ± 1075

†

ALB

11 ± 6

88 ± 46

59 ± 33

*#

3318 ± 1814

†

RA

15 ± 10

79 ± 37

92 ± 28

†

3731 ± 777

†

SHAM

20 ± 13

37 ± 19

37 ± 25

 

1683 ± 1396

 

Syndecan-1 (ng/ml)

   

Syndecan-1 (ng/kg)

FFP

15.3 ± 3.1

20.6 ± 6.1

19.5 ± 4.2

 

1061 ± 219

†

ALB

15.1 ± 4.8

16.5 ± 4.0

18.0 ± 5.0

 

970 ± 240

†

RA

16.1 ± 3.3

17.5 ± 4.5

22.6 ± 6.3

*†

906 ± 253

†

SHAM

16.3 ± 2.0

16.3 ± 3.1

14.5 ± 1.9

 

605 ± 145

 
  1. Values are means ± SD. The change in concentration after resuscitation compared to after haemorrhage within groups was evaluated with paired t test corrected for multiple analyses with the Bonferroni correction (*P < 0.05). Differences in between groups after resuscitation was analysed with one-way repeated measurement ANOVA followed by post hoc testing using the Newman-Keuls correction
  2. FFP fresh frozen plasma, ALB albumin, RA Ringer’s acetate
  3. #Significant difference compared to the Ringer’s acetate group
  4. †Significant difference compared to SHAM, P < 0.05
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