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Table 2 Excitability parameters

From: Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability

  Healthy subjects (n = 31) ICU controls (n = 12) CIP patients (n = 14) p a value p b value p c value
Temperature °C 33.94 (1.3) 34.5 (1.8) 34.8 (1.5) 0.399 0.075 0.705
(1) Current/threshold relationship
 Resting I/V slope 0.58 (0.01) 0.66 (0.04) 0.63 (0.03) 0.03 0.239 0.728
 Minimum I/V slope 0.26 (0.01) 0.28 (0.02) 0.26 (0.02) 0.536 0.781 0.406
 Hyperpol. I/V slope 0.4 (0.01) 0.31 (0.05) 0.44 (0.08) 0.225 0.263 0.079
(2) Stimulus response/strength duration
 Stimulus 50 % (mA) 4.66 (0.27) 5.52 (1.06) 8.6 (1.21) 0.282 0.001 0.075
 SDtc (ms) 0.51 (0.02) 0.56 (0.08) 0.4 (0.07) 0.759 <0.0001 0.03
 Rheobase (mA) 3.07 (0.22) 3.97 (0.58) 6.1 (0.87) 0.081 0.002 0.095
 Stimulus-response slope 6.39 (0.29) 4.51 (0.51) 4.61 (0.38) 0.004 0.003 1
(3) Threshold electrotonus (%)
 TEd40 (10–20 ms) 69.97 (1.69) 64.8 (2.04) 44.7 (11.1) 0.007 <0.0001 0.002
 TEh40 (10–20 ms) −74.15 (1.76) −76.92 (2.67) −66.65 (3.74) 0.841 0.028 0.051
 S240 accommodation 24.99 (1.03) 20.1 (1.33) 14.77 (1.97) 0.006 <0.0001 0.021
 TEd40 (90–100 ms) 45.19 (1.5) 43.59 (1.64) 44.29 (2.58) 0.123 0.17 0.932
 TEh40 (90–100 ms) −123.42 (3.37) −121.91 (8.76) −110.96 (7.61) 0.862 0.222 0.379
 TEh40 overshoot 15.88 (0.84) 14.64 (1.42) 9.39 (1.12) 0.342 <0.0001 0.004
 TEd40 undershoot −18.75 (0.74) −17.93 (1.38) −11.58 (1.64) 0.752 0.001 0.009
(4) Recovery of excitability
 RPR (ms) 3.06 (0.08) 2.98 (0.45) 3.06 (0.18) 0.874 0.8 0.968
 Superexcitability (%) −25.69 (1.09) −17.13 (2.74) −14.39 (2.05) 0.003 <0.0001 0.403
 Superexcitability at 7 ms −23.92 (1.19) −15.7 (2.41) −11.05 (1.8) 0.001 <0.0001 0.12
 Superexcitability at 5 ms −26.4 (1.17) −17.3 (2.85) −14.46 (2.26) 0.004 <0.0001 0.501
 Sub-excitability (%) 14.78 (0.91) 11.8 (1.7) 9.04 (0.92) 0.114 <0.0001 0.106
  1. Values are given as mean ± SE
  2. aHealthy subjects versus ICU control
  3. bHealthy subjects versus CIP patients
  4. cICU control versus CIP patients