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Table 2 Excitability parameters

From: Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability

 

Healthy subjects (n = 31)

ICU controls (n = 12)

CIP patients (n = 14)

p a value

p b value

p c value

Temperature °C

33.94 (1.3)

34.5 (1.8)

34.8 (1.5)

0.399

0.075

0.705

(1) Current/threshold relationship

 Resting I/V slope

0.58 (0.01)

0.66 (0.04)

0.63 (0.03)

0.03

0.239

0.728

 Minimum I/V slope

0.26 (0.01)

0.28 (0.02)

0.26 (0.02)

0.536

0.781

0.406

 Hyperpol. I/V slope

0.4 (0.01)

0.31 (0.05)

0.44 (0.08)

0.225

0.263

0.079

(2) Stimulus response/strength duration

 Stimulus 50 % (mA)

4.66 (0.27)

5.52 (1.06)

8.6 (1.21)

0.282

0.001

0.075

 SDtc (ms)

0.51 (0.02)

0.56 (0.08)

0.4 (0.07)

0.759

<0.0001

0.03

 Rheobase (mA)

3.07 (0.22)

3.97 (0.58)

6.1 (0.87)

0.081

0.002

0.095

 Stimulus-response slope

6.39 (0.29)

4.51 (0.51)

4.61 (0.38)

0.004

0.003

1

(3) Threshold electrotonus (%)

 TEd40 (10–20 ms)

69.97 (1.69)

64.8 (2.04)

44.7 (11.1)

0.007

<0.0001

0.002

 TEh40 (10–20 ms)

−74.15 (1.76)

−76.92 (2.67)

−66.65 (3.74)

0.841

0.028

0.051

 S240 accommodation

24.99 (1.03)

20.1 (1.33)

14.77 (1.97)

0.006

<0.0001

0.021

 TEd40 (90–100 ms)

45.19 (1.5)

43.59 (1.64)

44.29 (2.58)

0.123

0.17

0.932

 TEh40 (90–100 ms)

−123.42 (3.37)

−121.91 (8.76)

−110.96 (7.61)

0.862

0.222

0.379

 TEh40 overshoot

15.88 (0.84)

14.64 (1.42)

9.39 (1.12)

0.342

<0.0001

0.004

 TEd40 undershoot

−18.75 (0.74)

−17.93 (1.38)

−11.58 (1.64)

0.752

0.001

0.009

(4) Recovery of excitability

 RPR (ms)

3.06 (0.08)

2.98 (0.45)

3.06 (0.18)

0.874

0.8

0.968

 Superexcitability (%)

−25.69 (1.09)

−17.13 (2.74)

−14.39 (2.05)

0.003

<0.0001

0.403

 Superexcitability at 7 ms

−23.92 (1.19)

−15.7 (2.41)

−11.05 (1.8)

0.001

<0.0001

0.12

 Superexcitability at 5 ms

−26.4 (1.17)

−17.3 (2.85)

−14.46 (2.26)

0.004

<0.0001

0.501

 Sub-excitability (%)

14.78 (0.91)

11.8 (1.7)

9.04 (0.92)

0.114

<0.0001

0.106

  1. Values are given as mean ± SE
  2. aHealthy subjects versus ICU control
  3. bHealthy subjects versus CIP patients
  4. cICU control versus CIP patients