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Table 2 Excitability parameters
| Healthy subjects (n = 31) | ICU controls (n = 12) | CIP patients (n = 14) | p a value | p b value | p c value | |
|---|---|---|---|---|---|---|
| Temperature °C | 33.94 (1.3) | 34.5 (1.8) | 34.8 (1.5) | 0.399 | 0.075 | 0.705 |
| (1) Current/threshold relationship | ||||||
| Resting I/V slope | 0.58 (0.01) | 0.66 (0.04) | 0.63 (0.03) | 0.03 | 0.239 | 0.728 |
| Minimum I/V slope | 0.26 (0.01) | 0.28 (0.02) | 0.26 (0.02) | 0.536 | 0.781 | 0.406 |
| Hyperpol. I/V slope | 0.4 (0.01) | 0.31 (0.05) | 0.44 (0.08) | 0.225 | 0.263 | 0.079 |
| (2) Stimulus response/strength duration | ||||||
| Stimulus 50 % (mA) | 4.66 (0.27) | 5.52 (1.06) | 8.6 (1.21) | 0.282 | 0.001 | 0.075 |
| SDtc (ms) | 0.51 (0.02) | 0.56 (0.08) | 0.4 (0.07) | 0.759 | <0.0001 | 0.03 |
| Rheobase (mA) | 3.07 (0.22) | 3.97 (0.58) | 6.1 (0.87) | 0.081 | 0.002 | 0.095 |
| Stimulus-response slope | 6.39 (0.29) | 4.51 (0.51) | 4.61 (0.38) | 0.004 | 0.003 | 1 |
| (3) Threshold electrotonus (%) | ||||||
| TEd40 (10–20 ms) | 69.97 (1.69) | 64.8 (2.04) | 44.7 (11.1) | 0.007 | <0.0001 | 0.002 |
| TEh40 (10–20 ms) | −74.15 (1.76) | −76.92 (2.67) | −66.65 (3.74) | 0.841 | 0.028 | 0.051 |
| S240 accommodation | 24.99 (1.03) | 20.1 (1.33) | 14.77 (1.97) | 0.006 | <0.0001 | 0.021 |
| TEd40 (90–100 ms) | 45.19 (1.5) | 43.59 (1.64) | 44.29 (2.58) | 0.123 | 0.17 | 0.932 |
| TEh40 (90–100 ms) | −123.42 (3.37) | −121.91 (8.76) | −110.96 (7.61) | 0.862 | 0.222 | 0.379 |
| TEh40 overshoot | 15.88 (0.84) | 14.64 (1.42) | 9.39 (1.12) | 0.342 | <0.0001 | 0.004 |
| TEd40 undershoot | −18.75 (0.74) | −17.93 (1.38) | −11.58 (1.64) | 0.752 | 0.001 | 0.009 |
| (4) Recovery of excitability | ||||||
| RPR (ms) | 3.06 (0.08) | 2.98 (0.45) | 3.06 (0.18) | 0.874 | 0.8 | 0.968 |
| Superexcitability (%) | −25.69 (1.09) | −17.13 (2.74) | −14.39 (2.05) | 0.003 | <0.0001 | 0.403 |
| Superexcitability at 7 ms | −23.92 (1.19) | −15.7 (2.41) | −11.05 (1.8) | 0.001 | <0.0001 | 0.12 |
| Superexcitability at 5 ms | −26.4 (1.17) | −17.3 (2.85) | −14.46 (2.26) | 0.004 | <0.0001 | 0.501 |
| Sub-excitability (%) | 14.78 (0.91) | 11.8 (1.7) | 9.04 (0.92) | 0.114 | <0.0001 | 0.106 |
