Skip to main content

Table 2 Summary of animal studies utilizing P-APRV

From: The 30-year evolution of airway pressure release ventilation (APRV)

First author Year n Animal Study design %CPAP TLow Findings
Albert [49] 2011 22 Swine Randomized prospective, CPPV vs. LTV vs. APRV vs. HFOV 90 % 50–75 % PEF APRV increased oxygenation and ventilation with reduced cytokines compared to LTV
Roy [57] 2012 8 Swine Randomized prospective, CPPV vs. APRV 90 % 75 % PEF Early APRV prevented ARDS with improved oxygenation, histopathology, and surfactant protein preservation
Emr [62] 2013 16 Rat Randomized prospective, spont vs. CPPV vs. APRV 90 % 75 % PEF Early APRV prevented ARDS with improved oxygenation and histopathology
Roy [5] 2013 12 Swine Randomized prospective, sham vs. LTV vs. APRV 90 % 75 % PEF Early APRV prevented ARDS with improved oxygenation and histopathology with reduced inflammatory markers
Roy [61] 2013 9 Rat Randomized prospective, CPPV vs. APRV 90 % 75 % PEF Early APRV prevented ARDS with improved oxygenation and histopathology
Kollisch-Singule [55] 2014 8 Rat Randomized prospective, CPPV vs. APRV 90 % 10 or 75 % PEF APRV with low expiratory time reduced conducting airway microstrain
Kollisch-Singule [54] 2014 6 Rat Randomized prospective, CPPV with PEEP vs. APRV 90 % 10 or 75 % PEF APRV with low expiratory time reduced alveolar microstrain
Davies [52] 2015 22 Swine Randomized prospective, LTV vs. APRV 90 % 75 % PEF APRV increased oxygenation compared with LTV, APRV had a “trend towards” increased cerebral ischemia.
Arrindell [51] 2015 19 Preterm swine Randomized prospective, CPPV vs. APRV N/A 75 % PEF APRV increased oxygenation without change in histopathology or inflammatory markers
Kollisch-Singule [56] 2015 14 Rat Randomized prospective, uninjured vs. LTV vs. APRV 90 % 75 % PEF APRV approximated control lungs best with increased homogeneity compared to LTV. LTV with high PEEP reduced heterogeneity.
  1. Number of studies: 10
  2. T Low time at low pressure, CPPV conventional positive pressure ventilation, LTV low tidal volume ventilation, CPAP continuous positive airway pressure, PEF peak expiratory flow, SB spontaneous breathing, PEEP positive end-expiratory pressure, PIP peak inspiratory pressure