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Table 4 Summary of human trial utilizing P-APRV

From: The 30-year evolution of airway pressure release ventilation (APRV)

First author Year n Study design %CPAP TLow Findings
Yoshida [60] 2009 18 Retrospective case-control
LTV vs. APRV
N/A 50–75 % PEF APRV + SB had increased oxygenation and MAP and decreased atelectasis
Walsh [58] 2011 20 Retrospective case series
CPPV vs. APRV
>80 % 50–75 % PEF APRV improved pulmonary blood flow after tetralogy of fallot repair or cavopulmonary shunt
Andrews [50] 2013 66,099 Retrospective review
CPPV vs. early APRV
90 % 75 % PEF Early APRV decreased ARDS incidence tenfold and mortality threefold
Kawaguchi [53] 2014 13 Retrospective case series
CPPV vs. APRV
90 % 50–75 % PEF APRV safe in pediatric ARDS without hemodynamic compromise
Yehya [59] 2014 104 Retrospective cohort
HFOV vs. APRV
N/A 50–75 % PEF APRV had no mortality effect compared to oscillatory ventilation as rescue treatments
  1. Number of studies: 5
  2. T Low time at low pressure, CPPV conventional positive pressure ventilation, LTV low tidal volume ventilation, PEF peak expiratory flow, SB spontaneous breathing