The 30-year evolution of airway pressure release ventilation (APRV)

Intensive Care Medicine Experimental

Table 4 Summary of human trial utilizing P-APRV

First author	Year	n	Study design	%CPAP	T_Low	Findings
Yoshida [60]	2009	18	Retrospective case-control LTV vs. APRV	N/A	50–75 % PEF	APRV + SB had increased oxygenation and MAP and decreased atelectasis
Walsh [58]	2011	20	Retrospective case series CPPV vs. APRV	>80 %	50–75 % PEF	APRV improved pulmonary blood flow after tetralogy of fallot repair or cavopulmonary shunt
Andrews [50]	2013	66,099	Retrospective review CPPV vs. early APRV	90 %	75 % PEF	Early APRV decreased ARDS incidence tenfold and mortality threefold
Kawaguchi [53]	2014	13	Retrospective case series CPPV vs. APRV	90 %	50–75 % PEF	APRV safe in pediatric ARDS without hemodynamic compromise
Yehya [59]	2014	104	Retrospective cohort HFOV vs. APRV	N/A	50–75 % PEF	APRV had no mortality effect compared to oscillatory ventilation as rescue treatments

Number of studies: 5
T _Low time at low pressure, CPPV conventional positive pressure ventilation, LTV low tidal volume ventilation, PEF peak expiratory flow, SB spontaneous breathing