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Intensive Care Medicine Experimental

Table 3 Group-averaged plasma concentration of TNFα, IL-10 in pg/ml and IL-6 in ng/ml

From: Modulatory effects of vagal stimulation on neurophysiological parameters and the cellular immune response in the rat brain during systemic inflammation

 

TNFα (ng/ml)

IL-6 (ng/ml)

IL-10 (ng/ml)

SHAM

0.275 ± 0.080

2.15 ± 0.44

0.834 ± 0.260

SHAM + LPS

3.461 ± 0.645***

1251 ± 250***

5.619 ± 0.759***

LPS + VGX

3.384 ± 0.501***

916 ± 143***

7.642 ± 0.547***$

LPS + VGX + VNS

2.177 ± 0.193*#

549 ± 68**#

5.489 ± 0.514***

  1. Data are given as means ± standard error (SEM) together with statistical differences. Significance is given as: * compared with SHAM, *P < 0.05; **P < 0.01; ***P < 0.001; # compared with SHAM + LPS, # P < 0.05; $ compared with LPS + VGX, $ P < 0.05. TNFα: SHAM, n = 8, SHAM + LPS, LPS + VGX + VNS, n = 12, LPS + VGX, n = 13; IL-6, IL-10: SHAM, n = 8, SHAM + LPS, LPS + VGX, LPS + VGX + VNS, n = 13
  2. TNF tumor necrosis factor, IL interleukin, SHAM sham surgery, VGX bilateral vagotomy, VGX + VNS bilateral vagotomy and distal vagus nerve stimulation
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