Table 2 Representative genes in glycolytic pathway
From: Transcriptional reprogramming of metabolic pathways in critically ill patients
Symbols | Isoforms | Gene names | Functions | Roles in glycolysis | Our findings |
|---|---|---|---|---|---|
SLC2A | SLC2A1, SLC2A2, SLC2A3, SLC2A4, SLC2A5 | Solute carrier family 2 facilitated glucose transporter | Transport glucose molecules across the cell membrane | Provides glucose for glycolytic pathway | Up-regulation |
HK | HK1, HK2, HK3 | Hexokinase | Initiate glycolysis by conversion of glucose to glucose-6-phosphate | The first essential step in glycolysis | Up-regulation |
G6P | G6PC | Glucose-6-phosphate catalytic subunit | Hydrolyse glucose-6-phosphate to glucose | Reverse glycolysis | Down-regulation |
PK | PKM2, PKLR | Pyruvate kinase | Generates ATP and pyruvate as the final products | The final step in glycolysis | Up-regulation |
LDH | LDHA | Lactate dehydrogenase | Conversion of pyruvate to lactate | Post-glycolysis removal of pyruvate | Up-regulation |
LDHB | Lactate dehydrogenase | Convert lactate back to pyruvate | Provide pyruvate for mitochondria oxidation | Down-regulation |