Table 3 Representative genes in pentose phosphate pathway
From: Transcriptional reprogramming of metabolic pathways in critically ill patients
Symbols | Gene names | Functions | Roles in pentose phosphate pathway | Our findings |
|---|---|---|---|---|
G6PD | Glucose-6-phosphate dehydrogenase | Produce NADPH | Rate-controlling enzyme that initiates the pathway | Up-regulation |
PGD | Phosphogluconate dehydrogenase | Produce NADPH | Complete the oxidative phase of the pathway | Up-regulation |
PRPS1 | Phosphoribosyl pyrophosphate synthetase 1 | Support biosynthesis of nucleotide | Non-oxidative phase of the pathway | Down-regulation |
RPE | Ribulose-5-phosphate-3-epimerase | Support biosynthesis of nucleotide/amino acid and support glucose metabolism | Non-oxidative phase of the pathway | Down-regulation |