Table 4 Representative genes in tricarboxylic acid cycle (TCA) pathway
From: Transcriptional reprogramming of metabolic pathways in critically ill patients
Symbols | Isoforms | Gene names | Functions | Roles in TCA pathway | Our findings |
|---|---|---|---|---|---|
IDH | IDH3A, IDH3B | Isocitrate dehydrogenase | Decarboxylation of isocitrate to 2-oxoglutarate | Generate NADH and carbon dioxide | Down-regulation |
MDH2 | MDH2 | Malate dehydrogenase | Oxidation of malate to oxaloacetate | Generate NADH and carbon dioxide | Down-regulation |
PDHB | PDHB | Pyruvate dehydrogenase component beta | Convert pyruvate to acetyl-CoA | Entry point into the TCA pathway | Down-regulation |
PDHX | PDHX | Pyruvate dehydrogenase complex, component X | Convert pyruvate to acetyl-CoA. | Entry point into the TCA pathway | Down-regulation |
DLAT | DLAT | Pyruvate dehydrogenase complex dihydrolipoamide S-acetyltransferase | Convert pyruvate to acetyl-CoA. | Entry point into the TCA pathway | Down-regulation |