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Table 1 Physiological parameters (mean ± standard deviation (SD)) measured at different brain temperatures at baseline and during cooling and rewarming; SD was not shown if it was less than the last digit shown in the mean

From: A new approach to selective brain cooling by a Ranque-Hilsch vortex tube

  Baseline Cooling and maintenance phases Rewarming phase
1–45 min 1 h 2 h 3 h 4 h 5 h 6 h 7 h 1 h 2 h 3 h
Brain temp (°C) 38.1 ± 0.7 34.2 ± 1.1* 33.5 ± 0.4* 33.4 ± 0.6* 33.3 ± 0.6* 33.5 ± 0.7* 33.4 ± 0.4* 33.2 ± 0.6* 34.8 ± 0.3* 36.2 ± 0.2* 37.6 ± 0.3
SaO2 (%) 100 100 100 100 100 100 100 100 100 100 100
PaO2 (mmHg) 200 ± 51 225 ± 51 211 ± 53 213 ± 60 216 ± 67 210 ± 61 206 ± 51 200 ± 66 205 ± 52 204 ± 48 223 ± 36
cNa+ (mmol/L) 141 ± 2 140 ± 2 140 ± 2 140 ± 2 140 ± 2 139 ± 2 140 ± 2 139 ± 2 139 ± 2 139 ± 2 138 ± 2
cK+ (mmol/L) 4.5 ± 0.4 4.5 ± 0.3 4.8 ± 0.5 5.0 ± 0.6 4.9 ± 0.6 4.9 ± 0.6 4.9 ± 0.6 4.8 ± 0.6 4.8 ± 0.6 4.9 ± 0.7 4.9 ± 0.6
cCa2+ (mmol/L) 1.3 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3
cCl (mmol/L) 103 ± 2 103 ± 3 103 ± 3 103 ± 3 103 ± 2 102 ± 2 102 ± 3 102 ± 2 101 ± 2 100 ± 2 101 ± 2
MAP (mmHg) 74 ± 8 60 ± 5* 55 ± 6* 56 ± 6* 58 ± 9* 58 ± 10* 61 ± 8* 63 ± 11* 65 ± 11 66 ± 2 65 ± 3
HR (bpm) 126 ± 31 96 ± 9 91 ± 7* 89 ± 3* 90 ± 7* 88 ± 5* 88 ± 3* 92 ± 3* 92 ± 3* 91 ± 6* 93 ± 5*
pH 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5
tHb (g/dL) 9.1 ± 0.6 9.2 ± 0.4 9.2 ± 0.7 9.1 ± 0.5 9.1 ± 0.7 8.8 ± 0.9 9.2 ± 0.8 9.1 ± 0.8 8.7 ± 0.9 8.9 ± 0.6 9.0 ± 0.6
PaCO2 (mmHg) 39 ± 2 37 ± 3 37 ± 2 40 ± 1 38 ± 2 40 ± 1 38 ± 2 38 ± 2 40 ± 2 40 ± 2 41 ± 1
CBF (mL/100 g/min) 37 ± 2 N/A 25 ± 2 N/A 25 ± 3 N/A 28 ± 3 N/A N/A N/A 39 ± 4
  1. Omnibus ANOVA and post hoc Tukey test were used to detect changes of each monitored parameter over time
  2. *A statistically significant (p < 0.05) change compared to baseline
  3. SaO 2 oxygen saturation, P a O 2 partial pressure of oxygen, cNa + sodium concentration, cK + potassium concentration, cCa + calcium concentration, cCl chloride concentration, tHb total hemoglobin concentration, P a CO 2 partial pressure of carbon dioxide were measured in arterial blood samples, MAP mean arterial pressure, HR heart rate were measured from a femoral artery catheter, CBF cerebral blood flow, N/A not available data