Table 1 Physiological parameters (mean ± standard deviation (SD)) measured at different brain temperatures at baseline and during cooling and rewarming; SD was not shown if it was less than the last digit shown in the mean

Brain temp (°C)

38.1 ± 0.7

34.2 ± 1.1*

33.5 ± 0.4*

33.4 ± 0.6*

33.3 ± 0.6*

33.5 ± 0.7*

33.4 ± 0.4*

33.2 ± 0.6*

34.8 ± 0.3*

36.2 ± 0.2*

37.6 ± 0.3

S_aO₂ (%)

100

100

100

100

100

100

100

100

100

100

100

P_aO₂ (mmHg)

200 ± 51

225 ± 51

211 ± 53

213 ± 60

216 ± 67

210 ± 61

206 ± 51

200 ± 66

205 ± 52

204 ± 48

223 ± 36

cNa⁺ (mmol/L)

141 ± 2

140 ± 2

140 ± 2

140 ± 2

140 ± 2

139 ± 2

140 ± 2

139 ± 2

139 ± 2

139 ± 2

138 ± 2

cK⁺ (mmol/L)

4.5 ± 0.4

4.5 ± 0.3

4.8 ± 0.5

5.0 ± 0.6

4.9 ± 0.6

4.9 ± 0.6

4.9 ± 0.6

4.8 ± 0.6

4.8 ± 0.6

4.9 ± 0.7

4.9 ± 0.6

cCa²⁺ (mmol/L)

1.3

1.4

1.4

1.4

1.3

1.3

1.3

1.3

1.3

1.3

1.3

cCl⁻ (mmol/L)

103 ± 2

103 ± 3

103 ± 3

103 ± 3

103 ± 2

102 ± 2

102 ± 3

102 ± 2

101 ± 2

100 ± 2

101 ± 2

MAP (mmHg)

74 ± 8

60 ± 5*

55 ± 6*

56 ± 6*

58 ± 9*

58 ± 10*

61 ± 8*

63 ± 11*

65 ± 11

66 ± 2

65 ± 3

HR (bpm)

126 ± 31

96 ± 9

91 ± 7*

89 ± 3*

90 ± 7*

88 ± 5*

88 ± 3*

92 ± 3*

92 ± 3*

91 ± 6*

93 ± 5*

pH

7.5

7.5

7.5

7.5

7.5

7.5

7.5

7.5

7.5

7.5

7.5

tHb (g/dL)

9.1 ± 0.6

9.2 ± 0.4

9.2 ± 0.7

9.1 ± 0.5

9.1 ± 0.7

8.8 ± 0.9

9.2 ± 0.8

9.1 ± 0.8

8.7 ± 0.9

8.9 ± 0.6

9.0 ± 0.6

P_aCO₂ (mmHg)

39 ± 2

37 ± 3

37 ± 2

40 ± 1

38 ± 2

40 ± 1

38 ± 2

38 ± 2

40 ± 2

40 ± 2

41 ± 1

CBF (mL/100 g/min)

37 ± 2

N/A

25 ± 2

N/A

25 ± 3

N/A

28 ± 3

N/A

N/A

N/A

39 ± 4