Table 1 Patient characteristics at baseline
From: Heparin-binding protein is important for vascular leak in sepsis
|  | All patients (n = 341) | PaO2/FiO2 >100 (n = 283) | PaO2/FiO2 ≤100 (n = 53) | P value |
|---|---|---|---|---|
Male, n (%) | 201 (59) | 163 (57) | 37 (70) | 0.13 |
Age, years (median (IQR)) | 63 (50.6–72.4) | 63 (50.6–72.2) | 64 (49.8–73.6) | 0.93 |
Caucasian, n (%) | 307 (90) | 261 (92) | 42 (79) | <0.01 |
APACHE II (median (IQR)) | 26 (21–32) | 26 (21–32) | 29 (24–35) | <0.01 |
Comorbidities, n (%) | ||||
 Chronic heart failure | 26 (8) | 21 (7.4) | 5 (9.4) | 0.82 |
 COPD | 58 (17) | 53 (19) | 5 (9.4) | 0.15 |
 Chronic steroids | 72 (21) | 60 (21) | 11 (21) | 1.0 |
 Chronic dialysis | 30 (9) | 23 (8.1) | 6 (11) | 0.62 |
 Chronic hepatic failure | 37 (11) | 29 (10) | 8 (15) | 0.43 |
Infection site, n (%) | ||||
 Lung | 147 (43) | 112 (40) | 34 (64) | <0.01 |
 Abdomen | 89 (26) | 80 (28) | 8 (15) | 0.07 |
 Other | 105 (31) | 91 (32) | 11 (21) | 0.14 |
Physiological and laboratory variables at baseline, median (IQR) | ||||
 MAP (mmHg) | 56 (50–62) | 56 (50–62) | 55 (48–61) | 0.22 |
 Lactate (mmol/L) | 1.7 (0.9–3.4) | 1.6 (0.8–3.2) | 2.5 (1.3–5.0) | <0.01 |
 Norepinephrine (μg/min) | 13 (8–25) | 12 (8–22) | 23 (11–38) | <0.01 |
 WBC (109 cells/L) | 14 (8–21) | 14 (8–21) | 11 (7–19) | 0.18 |
 Platelets | 172 (90–259) | 174 (90–268) | 153 (108–238) | 0.25 |
 Temperature (°C) | 38.6 (37.7–39.3) | 38.5 (37.7–39.3) | 38.7 (37.8–39.2) | 0.49 |
 PaO2/FiO2 | 192 (142–260) | 205.3 (162–271) | 99 (82.5–110.8) | <0.01 |
 IL-6 (pM) | 4.3 (1.5–37) | 5.6 (1.5–24) | 18.9 (2.1–422) | <0.01 |
Outcomes other than mortality, median (IQR) | ||||
 DAF ventilator support | 9 (0–21) | 13 (1–22) | 0 (0–2) | <0.01 |
 DAF renal replacement therapy | 27 (7–28) | 28 (12–28) | 4 (1–16) | <0.01 |