Variable | Group | Time (hour) | Â | Â | Â | Â | Â |
---|---|---|---|---|---|---|---|
 |  | Baseline | 24 | 26 | 28 | 30 | 32 |
PaO2 (mmHg) | 108.9 ± 20.1 | 66.5 ± 18.5aa | 74.50 ± 5.79b | 84.67 ± 6.95b | 93.00 ± 5.18 | 101.0 ± 5.33 | |
HVHF | 106.9 ± 23.1 | 65.8 ± 19.8aa | 68.83 ± 3.19 | 74.17 ± 3.26 | 81.83 ± 1.94 | 89.50 ± 4.76 | |
Con. | 110.2 ± 21.9 | 68.0 ± 16.9aa | 58.50 ± 2.43 | 54.67 ± 2.73 | 51.00 ± 2.00 |  | |
MAP | 77.7 ± 2.07 | 54.50 ± 1.87a | 56.33 ± 1.63 | 58.33 ± 1.63 b | 60.50 ± 1.87 | 62.50 ± 1.87 | |
 | HVHF | 79.2 ± 1.93 | 52.83 ± 1.72a | 51.83 ± 1.33 | 50.33 ± 0.82 | 50.67 ± 1.75 | 52.53 ± 1.87 |
 | Con. | 76.9 ± 1.89 | 52.50 ± 1.87a | 50.00 ± 2.00 | 47.33 ± 2.25 | 44.83 ± 1.84 |  |
PAWP | 11.35 ± 2.85 | 22.00 ± 3.74a | 19.67 ± 2.58 | 17.67 ± 1.97b | 16.17 ± 1.47 | 14.00 ± 1.79 | |
 | HVHF | 11.48 ± 2.32 | 23.00 ± 3.74a | 22.33 ± 3.27 | 21.33 ± 3.20 | 20.50 ± 3.08 | 20.17 ± 3.43 |
 | Con. | 12.01 ± 3.07 | 20.50 ± 1.87a | 22.33 ± 3.01 | 24.00 ± 3.63 | 25.83 ± 3.76 |  |
CO | 2.29 ± 0.56 | 2.12 ± 0.25a | 2.10 ± 0.26 | 2.10 ± 0.28 b | 2.18 ± 0.27 | 2.19 ± 0.26 | |
 | HVHF | 2.33 ± 0.74 | 2.19 ± 0.27a | 2.09 ± 0.24 | 1.98 ± 0.22 | 1.82 ± 0.16 | 1.71 ± 0.17 |
 | Con. | 2.31 ± 0.42 | 2.18 ± 0.28a | 1.83 ± 0.28 | 1.53 ± 0.15 | 1.29 ± 0.10 |  |
Urine flow (ml/h) | 95.4 ± 0.87 | 18.33 ± 1.63a | 20.00 ± 1.41 | 23.00 ± 2.19 b | 26.17 ± 2.40 | 29.33 ± 2.34 | |
 | HVHF | 97.6 ± 0.90 | 20.00 ± 2.61a | 19.33 ± 2.16 | 18.67 ± 2.42 | 18.00 ± 2.28 | 17.50 ± 2.88 |
 | Con. | 96.5 ± 0.73 | 20.67 ± 2.42a | 15.67 ± 3.78 | 10.33 ± 3.89 | 6.17 ± 4.54 |  |
WBC ( × 109/L) | 13.8 ± 4.3 | 26.8 ± 5.3aa | 25.8 ± 4.9 | 23.6 ± 5.1 | 22.7 ± 4.5 | 20.8 ± 5.5 | |
 | HVHF | 12.9 ± 5.6 | 27.7 ± 5.9aa | 26.2 ± 6.1 | 24.5 ± 3.9 | 23.2 ± 6.8 | 21.9 ± 7.5 |
 | Con. | 15.1 ± 6.2 | 23.4 ± 4.2aa | 25.8 ± 7.3 | 24.4 ± 4.2 | 26.3 ± 4.4 |  |
Scr (μmol /l) | 83.5 ± 15.3 | 143.1 ± 76.4a | 131.2 ± 56.3 | 127.4 ± 26.8 | 109.7 ± 21.4 | 97.62 ± 23.5 | |
 | HVHF | 85.8 ± 12.5 | 134.7 ± 86.3a | 149.5 ± 66.7 | 142.3 ± 45.2 | 138.3 ± 33.4 | 120.5 ± 32.8 |
 | Con. | 81.5 ± 10.9 | 140.3 ± 80.4a | 155.9 ± 67.3 | 178.2 ± 55.4 | 195.8 ± 32.1 |  |
LAC (mmol/l) | 1.47 ± 0.42 | 4.28 ± 1.40a | 3.26 ± 1.12 | 2.21 ± 1.08b | 1.97 ± 0.76 | 1.74 ± 0.45 | |
 | HVHF | 1.58 ± 0.35 | 4.32 ± 1.18a | 3.47 ± 1.16 | 3.01 ± 0.97 | 2.14 ± 0.65 | 1.88 ± 0.56 |
 | Con. | 1.35 ± 0.52 | 3.94 ± 1.32a | 4.97 ± 1.54 | 5.87 ± 1.17 | 7.45 ± 0.49 |  |
Survival rate | 8/8 | 8/8 | 8/8 | 8/8 | 7/8 | 4/8 | |
 | HVHF | 8/8 | 8/8 | 6/8 | 4/8 | 2/8 | 2/8 |
 | Con. | 8/8 | 8/8 | 3/8 | 2/8 | 2/8 | 0/8 |