| T0 (baseline) | T1 (shock) | T2 (30 min) | T3 (120 min) |
---|---|---|---|---|
TNa+ (mmol/min−1) | ||||
 Time control | 15.3 ± 9.6 | 14.1 ± 7.0 | 18.8 ± 6.8 | 19.7 ± 4.7 |
 Control + NAC | 15.0 ± 6.4 | 13.2 ± 6.5 | 15.9 ± 6.5 | 9.5 ± 4.3** |
 LPS | 12.3 ± 5.5 | 0.00 ± 0.00*** | 0.00 ± 0.00*** | 0.00 ± 0.00*** |
 LPS + HES-RA | 12.0 ± 8.3 | 0.00 ± 0.00*** | 5.0 ± 1.12*** | 2.2 ± 1.3*** |
 LPS + HES-RA + NAC | 11.9 ± 5.7 | 0.00 ± 0.00*** | 2.8 ± 2.8*** | 2.2 ± 1.8*** |
VO2/TNa+ | ||||
 Time control | 1.77 ± 1.6 | 2.19 ± 1.3 | 1.59 ± 0.6 | 1.79 ± 0.7 |
 Control + NAC | 1.36 ± 0.4 | 2.19 ± 0.9 | 1.95 ± 1.18 | 6.32 ± 3.9 |
 LPS | 2.5 ± 1.2 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
 LPS + HES-RA | 2.24 ± 1.1 | 0.00 ± 0.00 | 6.06 ± 1.7 | 17.17 ± 7.1*, + |
 LPS + HES-RA + NAC | 1.97 ± 1.3 | 0.00 ± 0.0* | 23.36 ± 22.2 | 28.53 ± 28***, +++ |
ClCrea (ml/min) | ||||
 Time control | 0.11 ± 0.6 | 0.10 ± 0.04 | 0.14 ± 0.04 | 0.14 ± 0.03 |
 Control + NAC | 0.11 ± 0.04 | 0.09 ± 0.04 | 0.11 ± 0.04 | 0.06 ± 0.03*** |
 LPS | 0.09 ± 0.04 | 0.00 ± 0.00*** | 0.00 ± 0.00*** | 0.00 ± 0.00*** |
 LPS + HES-RA | 0.09 ± 0.06 | 0.00 ± 0.00*** | 0.05 ± 0.01***, + | 0.02 ± 0.01*** |
 LPS + HES-RA + NAC | 0.09 ± 0.04 | 0.00 ± 0.00*** | 0.04 ± 0.01*** | 0.02 ± 0.01*** |
EFNa+ | ||||
 Time control | 4.8 ± 4.7 | 13.2 ± 5.7 | 11.9 ± 4.9 | 10.4 ± 2.4 |
 Control + NAC | 2.3 ± 0.8 | 3.22 ± 1.7 | 2.9 ± 1.7 | 6.9 ± 6.6 |
 LPS | 3.7 ± 1.4 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
 LPS + HES-RA | 3.5 ± 2.8 | 0.00 ± 0.00 | 35.3 ± 7.3**, +++ | 17.1 ± 8.1 |
 LPS + HES-RA + NAC | 4.4 ± 3.9 | 0.00 ± 0.00 | 45.8 ± 36.7***, +++ | 31.4 ± 28.4***, +++ |
Urine volume (ml) | ||||
 Time control | 0.39 ± 0.14 | 0.53 ± 0.13 | 0.45 ± 0.13 | 0.19 ± 0.03 |
 Control + NAC | 0.25 ± 0.09 | 0.34 ± 0.17 | 0.2 ± 0.04 | 0.16 ± 0.06 |
 LPS | 0.31 ± 0.13 | 0.06 ± 0.09*** | 0.04 ± 0.05*** | 0.02 ± 0.05*** |
 LPS + HES-RA | 0.37 ± 0.3 | 0.12 ± 0.19*** | 0.6 ± 0.23 +++ | 0.16 ± 0.08 +++ |
 LPS + HES-RA + NAC | 0.33 ± 0.26 | 0.04 ± 0.09*** | 0.65 ± 0.47 +++ | 0.2 ± 0.13 +++ |