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Table 2 Parameters of renal function and excretion at different time points of the experiment

From: Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia

 

T0 (baseline)

T1 (shock)

T2 (30 min)

T3 (120 min)

TNa+ (mmol/min−1)

 Time control

15.3 ± 9.6

14.1 ± 7.0

18.8 ± 6.8

19.7 ± 4.7

 Control + NAC

15.0 ± 6.4

13.2 ± 6.5

15.9 ± 6.5

9.5 ± 4.3**

 LPS

12.3 ± 5.5

0.00 ± 0.00***

0.00 ± 0.00***

0.00 ± 0.00***

 LPS + HES-RA

12.0 ± 8.3

0.00 ± 0.00***

5.0 ± 1.12***

2.2 ± 1.3***

 LPS + HES-RA + NAC

11.9 ± 5.7

0.00 ± 0.00***

2.8 ± 2.8***

2.2 ± 1.8***

VO2/TNa+

 Time control

1.77 ± 1.6

2.19 ± 1.3

1.59 ± 0.6

1.79 ± 0.7

 Control + NAC

1.36 ± 0.4

2.19 ± 0.9

1.95 ± 1.18

6.32 ± 3.9

 LPS

2.5 ± 1.2

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

 LPS + HES-RA

2.24 ± 1.1

0.00 ± 0.00

6.06 ± 1.7

17.17 ± 7.1*, +

 LPS + HES-RA + NAC

1.97 ± 1.3

0.00 ± 0.0*

23.36 ± 22.2

28.53 ± 28***, +++

ClCrea (ml/min)

 Time control

0.11 ± 0.6

0.10 ± 0.04

0.14 ± 0.04

0.14 ± 0.03

 Control + NAC

0.11 ± 0.04

0.09 ± 0.04

0.11 ± 0.04

0.06 ± 0.03***

 LPS

0.09 ± 0.04

0.00 ± 0.00***

0.00 ± 0.00***

0.00 ± 0.00***

 LPS + HES-RA

0.09 ± 0.06

0.00 ± 0.00***

0.05 ± 0.01***, +

0.02 ± 0.01***

 LPS + HES-RA + NAC

0.09 ± 0.04

0.00 ± 0.00***

0.04 ± 0.01***

0.02 ± 0.01***

EFNa+

 Time control

4.8 ± 4.7

13.2 ± 5.7

11.9 ± 4.9

10.4 ± 2.4

 Control + NAC

2.3 ± 0.8

3.22 ± 1.7

2.9 ± 1.7

6.9 ± 6.6

 LPS

3.7 ± 1.4

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

 LPS + HES-RA

3.5 ± 2.8

0.00 ± 0.00

35.3 ± 7.3**, +++

17.1 ± 8.1

 LPS + HES-RA + NAC

4.4 ± 3.9

0.00 ± 0.00

45.8 ± 36.7***, +++

31.4 ± 28.4***, +++

Urine volume (ml)

 Time control

0.39 ± 0.14

0.53 ± 0.13

0.45 ± 0.13

0.19 ± 0.03

 Control + NAC

0.25 ± 0.09

0.34 ± 0.17

0.2 ± 0.04

0.16 ± 0.06

 LPS

0.31 ± 0.13

0.06 ± 0.09***

0.04 ± 0.05***

0.02 ± 0.05***

 LPS + HES-RA

0.37 ± 0.3

0.12 ± 0.19***

0.6 ± 0.23 +++

0.16 ± 0.08 +++

 LPS + HES-RA + NAC

0.33 ± 0.26

0.04 ± 0.09***

0.65 ± 0.47 +++

0.2 ± 0.13 +++

  1. Values are presented as mean ± SD
  2. TNa+ tubular sodium reabsorption, Cl creat clearance of creatinine, LPS lipopolysaccharide, HES-RA hydroxyethyl starch-ringer acetate, NAC N-acetylcysteine
  3. *p < 0.05, **p < 0.01, and ***p < 0.001 versus control; + p < 0.05 and +++ p < 0.001 versus LPS