Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema

Padilha, Gisele de A.; Horta, Lucas F. B.; Moraes, Lillian; Braga, Cassia L.; Oliveira, Milena V.; Santos, Cíntia L.; Ramos, Isalira P.; Morales, Marcelo M.; Capelozzi, Vera Luiza; Goldenberg, Regina C. S.; de Abreu, Marcelo Gama; Pelosi, Paolo; Silva, Pedro L.; Rocco, Patricia R. M.

doi:10.1186/s40635-016-0107-0

Intensive Care Medicine Experimental

Table 1 Respiratory parameters

From: Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema

Parameter	Group		T0	T2	T4	Time effect	Group effect	Interaction
V _T (mL.kg⁻¹)	Control	PCV	5.9 ± 0.4	5.7 ± 0.5	5.7 ± 0.5	ns	ns	ns
	Control	PSV	6.5 ± 0.9	6.6 ± 1.0	6.6 ± 0.7
	Emphysema	PCV	6.0 ± 1.0	5.9 ± 0.6	6.1 ± 0.5
	Emphysema	PSV	6.1 ± 1.1	6.3 ± 1.1	6.3 ± 1.1
RR (breaths.min⁻¹)	Control	PCV	62.1 ± 4.7	62.1 ± 4.6	62.2 ± 4.5	p < 0.05	p < 0.001	p < 0.05
	Control	PSV	39.8 ± 4.9*	44.9 ± 5.6*	54.6 ± 12.7
	Emphysema	PCV	59.5 ± 4.0	60.8 ± 2.9	59.8 ± 3.5
	Emphysema	PSV	56.7 ± 10.8**	52.9 ± 7.8	62.0 ± 11.0
Ti/Ttot (s)	Control	PCV	0.35 ± 0.00	0.35 ± 0.01	0.35 ± 0.00	ns	p < 0.05	ns
	Control	PSV	0.31 ± 0.10	0.31 ± 0.07	0.32 ± 0.05
	Emphysema	PCV	0.35 ± 0.00	0.35 ± 0.00	0.35 ± 0.01
	Emphysema	PSV	0.29 ± 0.05	0.27 ± 0.02***	0.31 ± 0.06
Ppeak,L (cmH₂O)	Control	PCV	10.8 ± 1.9	11.2 ± 1.5	12.1 ± 1.4	ns	p < 0.01	p < 0.05
	Control	PSV	12.6 ± 1.8	13.0 ± 2.2	12.3 ± 3.1
	Emphysema	PCV	11.3 ± 1.5	12.2 ± 1.5	13.5 ± 1.3
	Emphysema	PSV	15.9 ± 2.0^, *	15.7 ± 1.7	14.3 ± 2.3
Pmean,L (cmH₂O)	Control	PCV	5.8 ± 0.7	5.8 ± 06	6.3 ± 0.4	p < 0.05	p < 0.001	ns
	Control	PSV	4.8 ± 0.6	5.1 ± 0.6	5.0 ± 0.7*
	Emphysema	PCV	5.9 ± 0.6	6.2 ± 0.6	6.7 ± 0.4
	Emphysema	PSV	5.8 ± 0.6**	5.5 ± 0.4	5.3 ± 0.5***
PTP/min (cmH₂O.s.min⁻¹)	Control	PCV	–	–	–	ns	ns	ns
	Control	PSV	13.9 ± 13.3	14.8 ± 12.5	17.5 ± 17.8
	Emphysema	PCV	–	–	–
	Emphysema	PSV	18.5 ± 15.0	14.9 ± 13.5	30.4 ± 14.3
P _0.1 (cmH₂O)	Control	PCV	–	–	–	ns	ns	ns
	Control	PSV	−1.03 ± 0.93	−1.25 ± 0.90	−1.48 ± 0.83
	Emphysema	PCV	–	–	–
	Emphysema	PSV	−1.47 ± 0.97	−1.47 ± 1.20	−2.49 ± 1.41
CV of V _T (%)	Control	PCV	0.8 ± 0.6	2.1 ± 1.8	2.7 ± 3.7	ns	p < 0.0001	ns
	Control	PSV	6.4 ± 3.9	8.0 ± 4.6*	9.5 ± 3.5*
	Emphysema	PCV	1.9 ± 1.5	2.2 ± 1.5	2.4 ± 1.6
	Emphysema	PSV	6.0 ± 3.1	7.2 ± 4.5	7.7 ± 7.3
CV of RR (%)	Control	PCV	0.7 ± 0.0	1.3 ± 0.0	2.4 ± 0.0	ns	p < 0.001	ns
	Control	PSV	49.5 ± 0.3*	48.0 ± 0.4*	34.7 ± 0.2*
	Emphysema	PCV	0.6 ± 0.0	0.6 ± 0.0	1.3 ± 0.0
	Emphysema	PSV	21.0 ± 0.2^, *	20.9 ± 0.1^, *	18.4 ± 0.1^, *
CV of Ti/Ttot (%)	Control	PCV	1.3 ± 0.5	1.6 ± 0.7	1.8 ± 0.7	ns	p < 0.0001	ns
	Control	PSV	30.0 ± 7.7*	27.6 ± 11.3*	24.1 ± 8.7*
	Emphysema	PCV	0.9 ± 0.3	1.3 ± 0.6	1.6 ± 0.9
	Emphysema	PSV	17.0 ± 9.7^, *	20.2 ± 10.2***	18.8 ± 7.1***

Values are means ± SD of 6 animals
PCV pressure-controlled ventilation, PSV pressure support ventilation, V _T tidal volume, CV of V _T coefficient of variation of tidal volume, RR respiratory rate, CV of RR coefficient of variation of respiratory rate, Ti/Ttot inspiratory time divided by total respiratory cycle time, CV of Ti/Ttot coefficient of variation on inspiratory time divided by total respiratory cycle time, Ppeak,L transpulmonary peak pressure, Pmean,L transpulmonary mean pressure, PTP/min pressure–time product per minute, P _0.1 esophageal pressure generated 100 ms after onset of inspiratory effort
*Significantly different from control-PCV (p < 0.05); **significantly different from Control-PSV (p < 0.05); ***significantly different from emphysema-PCV (p < 0.05)

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