Fig. 6
From: Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis
Reduced kidney injury in HDC−/− mice following CLP-induced sepsis. a, b Serum levels of BUN and creatinine. Blood samples were collected from sham-operated and CLP-induced septic mice 18 h after surgery (n = 4–11/group). All values are provided as means ± SEM. ***P < 0.001 vs. the respective control (18 h after sham operation). # P < 0.05 and ## P < 0.01 vs. CLP WT. c, d Representative micrographs liver sections stained with hematoxylin and eosin and anti-NGAL antibody followed by peroxidase staining. Original magnification, ×200. The same results were obtained with two other experiments. e Western blot image of NGAL protein expression. GAPDH served as loading control. Shown are representative blots from three independent experiments in which the same results were obtained. Tissues were harvested from sham-operated and CLP-induced septic mice 24 h after surgery