Fig. 8
From: Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis
Reduced tissue injury in H1R−/−/H2R−/− mice following CLP-induced sepsis. a Blood levels of IL-6 and MCP-1. b Representative micrographs of tissue sections stained with hematoxylin and eosin, anti-MPO antibody, and anti-NGAL antibody. Lung, liver, and kidney tissues were harvested from sham-operated and CLP-induced septic mice 24 h after surgery. Original magnification, ×200 or ×400. The same results were obtained with two other experiments. c Serum levels of ALT. d Serum levels of BUN and creatinine. Blood and tissue samples were taken at 18 h after surgery (n = 5–8). All values are provided as means ± SEM. # p < 0.05 vs. CLP WT