Fig. 9

Effects of treatment with d-chlorpheniramine and famotidine on elevated blood cytokines and organ injury following CLP-induced sepsis. a Blood levels of IL-6 and MCP-1. b Representative micrographs of tissue sections stained with hematoxylin and eosin, anti-MPO antibody, and anti-NGAL antibody. Lung, liver, and kidney tissues were harvested from sham-operated and CLP-induced septic mice 24 h after surgery. Original magnification, ×200 or ×400. The same results were obtained with two other experiments. c Serum levels of ALT. d Serum levels of BUN and creatinine. Blood and tissue samples were taken at 18 h after surgery (n = 6–10/group). All values are provided as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. the respective sham control. ^# p < 0.05, ^## p < 0.01 vs. CLP alone