Skip to main content
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis

Fig. 1

Leukocyte recruitment in the hepatic microcirculation in response to resuscitation with novel or traditional crystalloids. Intravital microscopy was used to measure leukocyte rolling (a) and adhesion (b) in hepatic post-sinusoidal venules, as well as sinusoidal leukocyte adhesion (c) and blood flow (d) in CLP or sham mice at 6 h after surgery. All mice were resuscitated with either 20 mL/kg of Ringer’s lactate, normal saline, or novel Seplyte L or H fluids, in accordance with clinical dosing practice. Fluids were administered intravenously immediately following surgery and 4 h later. Data are presented as mean ± SEM with n = 6–8 for all groups. ***p < 0.001; asterisk directly above error bar indicates comparison to sham control. CLP cecal ligation and puncture, RL Ringer’s lactate, NS normal saline, SepL Seplyte L, SepH Seplyte H

Back to article page