Fig. 1From: Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsisLeukocyte recruitment in the hepatic microcirculation in response to resuscitation with novel or traditional crystalloids. Intravital microscopy was used to measure leukocyte rolling (a) and adhesion (b) in hepatic post-sinusoidal venules, as well as sinusoidal leukocyte adhesion (c) and blood flow (d) in CLP or sham mice at 6 h after surgery. All mice were resuscitated with either 20 mL/kg of Ringer’s lactate, normal saline, or novel Seplyte L or H fluids, in accordance with clinical dosing practice. Fluids were administered intravenously immediately following surgery and 4 h later. Data are presented as mean ± SEM with n = 6–8 for all groups. ***p < 0.001; asterisk directly above error bar indicates comparison to sham control. CLP cecal ligation and puncture, RL Ringer’s lactate, NS normal saline, SepL Seplyte L, SepH Seplyte HBack to article page