Healthy subjects (n = 35) | SIRS (n = 40) | Sepsis (n = 48)d | Statistic value x 2 or H 2 | Effect size (w 2 or V)** | P value*** | |
---|---|---|---|---|---|---|
Age (years)e | 35 (28–50)a | 41 (32–53)c | 58 (44–69)a, c | 34 | 0.29 | <0.001 |
Gender (male/female) | 19/16 | 31/9 | 28/20 | 5.2 | 0.21 | 0.07 |
Mortality in ICU (died/survived (%)) | 0/35 | 5/35 (12.5%) | 21/27 (43.8%) | 10.2 | 0.34 | 0.001 |
Mortality in hospital (died/survived (%)) | 0/35 | 6/34 (15.8%) | 29/19 (60.4%) | 17.5 | 0.45 | <0.001 |
LOS (days) | NA | 15.5 (7–28.5) | 18.5 (9.2–36.8) | 2 | 0.03 | 0.16 |
APACHE II | NA | 15 (10–18)c | 21 (16–27)c | 15 | 0.19 | <0.001 |
SOFA | NA | 9 (7–11)c | 11 (9–13)c | 11 | 0.14 | 0.001 |
SAPS III | NA | 41 (43–58)c | 41 (61–78)c | 32 | 0.44 | <0.001 |
CRP (mg/dl) | NA | 7.1 (1.05–15)c | 21 (8.8–27)c | 10.5 | 0.15 | 0.001 |
PCT (ng/ml) | NA | 0.9 (0.5–1.8)c | 5.2 (1–34)c | 7 | 0.23 | 0.008 |
Lactate | NA | 2.4 (1.4–4.2) | 2.8 (1.3–5) | 0.23 | 0.00 | 0.63 |
Glucose (mg/dl) | NA | 154 (128–189)c | 219 (145–299)c | 8.6 | 0.12 | 0.003 |
Albumin (g/dl) | NA | 3 (2.3–3.4)c | 2.5 (2.1–2.9)c | 6.3 | 0.09 | 0.012 |
WBC (K/μl) | NA | 11.4 (7.3–15.5) | 10.9 (2.6–19.9) | 0.12 | 0.00 | 0.91 |
hGRα mRNA (fold change) | 0.50 (0.12–0.9)a | 0.64 (0.32–0.77) | 0.74 (0.52–1.23)a | 8.3 | 0.08 | 0.016 |
hGR (MFI) | 0.95 (0.76–1.9)a | 1.1 (0.43–2.5)c | 3.3 (1.6–4.6)a, c | 9.6 | 0.28 | 0.008 |
Prolactin (ng/ml) | 7.5 (5–10)a b | 18.3 (11–25)b | 15.4 (9–32)a | 20.4 | 0.17 | <0.001 |
Cortisol (μg/dl) | 12.3 (9–15)a | 16.2 (11–23)c | 32.8 (21–67)a, c | 38.6 | 0.33 | <0.001 |
ACTH (pg/ml) | 17.5 (13–33)b | 10 (6–19)b, c | 18.6 (10–38)c | 10.4 | 0.09 | –0.005 |
eHSP90α (ng/ml) | 10.5 (1.2–23)a, b, c | 32 (22–57)b, c | 71 (31–124)a, c | 39.5 | 0.33 | <0.001 |
eHSP72 (ng/ml) | 0.26 (0.14–0.41)a | 0.29 (0.19–0.49)c | 0.95 (0.41–2.5)a, c | 32 | 0.29 | <0.001 |
mHSP90α (MFI) | 24 (12–82) | 36 (10.5–64) | 33 (7.6–56) | 0.07 | 0.00 | 0.96 |
mHSP72 (MFI) | 19.6 (13–32) | 22.8 (11–52) | 18 (11.7–30.7) | 0.84 | 0.01 | 0.65 |
nHSP90α (MFI) | 11 (5.4–25) | 17 (4.8–25) | 18.3 (6.8–38) | 3.5 | 0.03 | 0.17 |
nHSP72 (MFI) | 77 (44–110)a | 75 (28–154)c | 40 (25–65)a, c | 13.7 | 0.12 | 0.001 |
IL-6 (pg/ml) | 1.4 (0.98–2.5)a, b | 77 (21–213)b | 203 (60–539)a | 72 | 0.60 | <0.001 |
IL-10 (ng/ml) | 0.01 (0.1–9.5) a | 4.9 (0.1–11)c | 48 (0.1–58)a, c | 15.6 | 0.13 | <0.001 |
IL-17 (ng/ml) | 0.2 (0.2–33) | 0.2 (0.2–6.4) | 0.2 (0.2–7.8) | 0.05 | 0.00 | 0.98 |
IFN-γ (pg/ml) | 6.2 (0.44–9.8) | 4.7 (0.13–7.8)c | 9.7 (4–17)c | 12 | 0.10 | 0.03 |