Intensive Care Medicine Experimental

Table 2 Receiver operating characteristic curve analysis to determine the optimum cutoff values and the positive and negative predictive values of hGR, cortisol, and HSPs for the prediction of sepsis in ICU patients

From: Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality

	Parameters
Biomarkers	AUROC (95% CI)	P value	Sensitivity	Specificity	J	Cutoff	PPV (%)	NPV (%)
eHSP72	0.94 (0.84–1.0)	0.001	0.88	0.79	0.66	0.40	73	68
Cortisol	0.90 (0.77–1.0)	0.002	1.00	0.79	0.79	15.7	66	70
hGR MFI	0.85 (0.69–1.0)	0.008	0.88	0.79	0.66	2.66	73	49
eHSP90α	0.80 (0.62–0.99)	0.02	0.75	0.79	0.54	66.0	72	56
hGRα mRNA	0.75 (0.52–0.98)	0.05	0.75	0.86	0.61	0.38	66	67

Abbreviations: AUROC area under the receiver operating characteristic curve, CI confidence interval, J Youden’s index, PPV positive predictive value, NPV negative predictive value, eHSP extracellular heat shock protein, hGR human glucocorticoid receptor, MFI mean fluorescent intensity

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