Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure

Kei, Tiffanie; Mistry, Nikhil; Tsui, Albert K. Y.; Liu, Elaine; Rogers, Stephen; Doctor, Allan; Wilson, David F.; Desjardins, Jean-Francois; Connelly, Kim; Mazer, C. David; Hare, Gregory M. T.

doi:10.1186/s40635-017-0125-6

Intensive Care Medicine Experimental

Table 2 Arterial and venous blood gases following starch (HES) and saline hemodilution

From: Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure

		Arterial blood samples				Venous blood samples
		Baseline	Post-hemodilution	30 min	60 min	Baseline	Post-hemodilution	30 min	60 min
pH	Control	7.35 ± 0.03	7.32 ± 0.02	7.33 ± 0.01	7.31 ± 0.02	7.33 ± 0.04	7.30 ± 0.03	7.30 ± 0.02	7.28 ± 0.02
	HES	7.37 ± 0.02	7.34 ± 0.02	7.36 ± 0.03	7.37 ± 0.04	7.35 ± 0.02	7.33 ± 0.02	7.33 ± 0.02	7.33 ± 0.04
	Saline	7.37 ± 0.04	7.34 ± 0.04	7.31 ± 0.07	7.24 ± 0.18*	7.35 ± 0.03	7.28 ± 0.05	7.26 ± 0.1*	7.08 ± 0.15*$#
pCO₂ (mmHg)	Control	39.3 ± 4.5	40.3 ± 2.6	38.7 ± 2.5	41.5 ± 5.1	44.2 ± 7.7	47.8 ± 5.1	45.6 ± 2.6	46.9 ± 5.7
	HES	39.6 ± 5.2	41.7 ± 3.4	40.5 ± 4.7	37.0 ± 6.2	44.3 ± 3.5	44.3 ± 4.3	42.7 ± 4.7	42.5 ± 5.3
	Saline	37.9 ± 3.8	36.6 ± 4.1	28.3 ± 4.1*$#	25.3 ± 10*$#	41.7 ± 4.1	44.8 ± 4.8	39.6 ± 8.7	46.6 ± 5.8
pO₂ (mmHg)	Control	88.1 ± 6.1	87.2 ± 6.9	84.3 ± 8.4	82.3 ± 22.4	50 ± 8.3	49 ± 5.3	46.8 ± 4.0	41.9 ± 3.9*
	HES	77.3 ± 8.3	76 ± 10.6	71.9 ± 13.6	82 ± 18.4	47.4 ± 2.6	42.3 ± 2.8*	38.6 ± 4.3*$	34.7 ± 2.5*
	Saline	79.8 ± 8.6	87.7 ± 15.1	103.2 ± 10.4*	88.4 ± 18.5	47.9 ± 4.2	33.1 ± 5.9*$#	32.5 ± 7.5*$	23.6 ± 5.1*$#
HCO₃ ^- (mmol/L)	Control	20.9 ± 2.1	20.3 ± 1.3	19.7 ± 0.7	20.3 ± 1.7	22.5 ± 2.9	22.6 ± 1.9	21.6 ± 1.4	21.5 ± 2.3
	HES	22.5 ± 2.0	22.3 ± 1.8	22.1 ± 1.8	20.8 ± 1.6	23.8 ± 1.3	22.5 ± 1.9	21.7 ± 1.7*	21.6 ± 1.4*
	Saline	21.5 ± 0.8	19.2 ± 0.8	13.9 ± 1.9*$#	10.8 ± 5.4*$#	22.5 ± 1.6	20.4 ± 1.3*	16.8 ± 1.8*$#	13.7 ± 3.6*$#
Lactate (mmol/L)	Control	2.4 ± 0.6	2.7 ± 0.6	2.6 ± 0.73	2.7 ± 0.7	2.5 ± 0.6	3.0 ± 0.3	3.0 ± 0.4	2.9 ± 1.0
	HES	2.5 ± 0.5	2.5 ± 0.7	2.8 ± 0.9	3.2 ± 0.9	2.5 ± 0.5	2.4 ± 0.6	2.4 ± 0.6	2.8 ± 0.7
	Saline	3.5 ± 1.3	3.3 ± 1.2	6.5 ± 2.2*$#	10.9 ± 6.2*$#	3.1 ± 1.0	3.8 ± 1.0	6.4 ± 1.7*$#	10.6 ± 5.1*$#

*p < 0.001 vs. baseline, $p < 0.001 vs. control, #p < 0.001 vs. HES and control

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