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Table 1 Micro-computerized tomography (micro-CT scan) analysis, histological assessment, and cytokine concentrations in bronchoalveolar lavage (BAL) and plasma in 24 h from induction of acid aspiration acute lung injury in wild-type mice

From: Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice

Treatment Wild-type mice with acid aspiration acute lung injury
24 h
Micro-CT scan Histology Cytokines
Change in the extent of alveolar collapse between 1 and 24 h (%)
(n)
Alveolar sero-fibrinous exudate
(visual score)
(n)
Alveolar hemorrhage
(visual score)
(n)
BAL CXCL1
(pg/ml)
(n)
BAL TNF-α
(pg/ml)
(n)
Plasma PTX3
(ng/ml)
(n)
PBS 0.0 ± 10.9
(21)
1.0 [0.1–3.2]
(7)
0.3 [0.0–3.2]
(7)
35.8 [2.0–63.6] (18) 32.5 [32.0–73.0]
(18)
296 [218–408]
(15)
WT-MSCs −8.1 ± 10.3*
(17)
1.5 [0.2–1.9]
(7)
0.1 [0.0–0.7]
(7)
1.0 [0.1–30.1]§
(17)
29.0 [26.5–33.3]§
(17)
200 [155–275]
(10)
PTX3−/−-MSCs 3.3 ± 10.3*
(13)
0.1 [0.0–0.3]
(5)
0.3 [0.0–0.9]
(5)
34.5 [28.0–40.8] (9) 21.0 [15.8–25.8]§
(9)
275 [244–372]
(15)
p value
ANOVA or Kruskal–Wallis
0.01 0.07 0.50 <0.05 <0.05 0.142
  1. CXCL1 keratinocyte chemoattractant, TNF-α tumor necrosis factor-α, PTX3 pentraxin 3
  2. *Dunnett’s post hoc p < 0.05 vs. PBS
  3. §Dunn’s post hoc p < 0.05 vs. PBS