Table 1 Micro-computerized tomography (micro-CT scan) analysis, histological assessment, and cytokine concentrations in bronchoalveolar lavage (BAL) and plasma in 24Â h from induction of acid aspiration acute lung injury in wild-type mice
Treatment | Wild-type mice with acid aspiration acute lung injury | |||||
|---|---|---|---|---|---|---|
24Â h | ||||||
Micro-CT scan | Histology | Cytokines | ||||
Change in the extent of alveolar collapse between 1 and 24 h (%) (n) | Alveolar sero-fibrinous exudate (visual score) (n) | Alveolar hemorrhage (visual score) (n) | BAL CXCL1 (pg/ml) (n) | BAL TNF-α (pg/ml) (n) | Plasma PTX3 (ng/ml) (n) | |
PBS | 0.0 ± 10.9 (21) | 1.0 [0.1–3.2] (7) | 0.3 [0.0–3.2] (7) | 35.8 [2.0–63.6] (18) | 32.5 [32.0–73.0] (18) | 296 [218–408] (15) |
WT-MSCs | −8.1 ± 10.3* (17) | 1.5 [0.2–1.9] (7) | 0.1 [0.0–0.7] (7) | 1.0 [0.1–30.1]§ (17) | 29.0 [26.5–33.3]§ (17) | 200 [155–275] (10) |
PTX3−/−-MSCs | 3.3 ± 10.3* (13) | 0.1 [0.0–0.3] (5) | 0.3 [0.0–0.9] (5) | 34.5 [28.0–40.8] (9) | 21.0 [15.8–25.8]§ (9) | 275 [244–372] (15) |
p value ANOVA or Kruskal–Wallis | 0.01 | 0.07 | 0.50 | <0.05 | <0.05 | 0.142 |