Fig. 7

The effect of administration of a superoxide dismutase inhibitor on renal blood flow, superoxide dismutase activity and 3-nitrotyrosine content after sepsis induction. Immediately after sepsis induction, a SOD inhibitor, diethyldithiocarbamic acid diethylammonium (DETC, i.v. 7.5 mg/kg), was administered. Several times after sepsis induction (12, 24 and 48 h), renal blood flow was measured and (a) expressed as a percentage difference compared to the sham group; superoxide dismutase activity (b) was expressed in SOD (U/mg protein), and the 3-nitrotyrosine content (c) was expressed in nitrotyrosine content (arbitrary units). The dotted line represents sham renal blood flow. The values are presented as the mean ± S.E.M., n = 6 in each group. *p < 0.05, compared to CLP without SOD inhibitor at the same time point