Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis

Intensive Care Medicine Experimental

Table 1 Baseline characteristics and echocardiographic metrics for C57BL/6J mice

Variable	CLP (33)	Sham (25)	Control (10)	p
Weight (g)	22.42 ± 2.7	21.66 ± 3.31	20.5 ± 2.1	0.44
HR (bpm)	436 ± 65	431 ± 73	444 ± 62	0.87
2D Echo
EF (%)	0.59 ± 0.1	0.59 ± 0.09	0.62 ± 0.09	0.57
Doppler
E/A	1.6 ± 0.23	1.57 ± 0.18	1.57 ± 0.23	0.71
E/e’	25.2 ± 7.3	24.8 ± 5.0	27.3 ± 7.9	0.56
Strain
CS (%)	−28.04 ± 5.74	−27.44 ± 5.7	−26.9 ± 4.4	0.87
CSR (%)	−11.45 ± 3.8	−10.5 ± 2.4	−9.6 ± 2.2	0.54
LS (%)	−21.3 ± 4.31	−22.23 ± 4.31	−23.43 ± 6.02	0.67
LSR (%)	−7.45 ± 1.9	−8.97 ± 2.96	−9.98 ± 4.7	0.04

CLP indicates cecal ligation and puncture, CS global circumferential strain, CSR peak systolic circumferential strain rate, E/A ratio of peak flow velocity across the mitral annulus during early and late diastole, 2D Echo conventional echocardiography, E/e’ ratio between mitral inflow and mitral annular excursion velocity during early diastole, EF ejection fraction, LS global longitudinal strain, LSR peak systolic longitudinal strain rate, Strain strain echocardiography