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Table 2 Echocardiographic metrics at 24 and 48 h post-CLP for C57BL/6J mice

From: Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis

Parameter

CLP

Sham

Control

p

24 h post-CLP

 HR (bpm)

453 ± 65

463 ± 58

465 ± 46

0.77

2D Echo

 EF (%)

0.58 ± 0.11

0.57 ± 0.07

0.61 ± 0.08

0.68

 E/A

1.45 ± 0.44

1.49 ± 0.23

1.49 ± 0.22

0.88

 E/e’

19.1 ± 8.44

20.83 ± 6.65

22.9 ± 4.73

0.34

Strain

 CS (%)

−22.3 ± 5.7

−23.4 ± 10.75

−25.14 ± 3.18

0.26

 CSR (%)

−9.6 ± 3.48

−12.14 ± 6.21

−10.69 ± 3.27

0.54

 LS (%)

−16.6 ± 4.12

−21.01 ± 5.4

−22.5 ± 3.9

<0.01**

 LSR (%)

−7.08 ± 2.52

−7.84 ± 2.23

−9.01 ± 2.36

0.08

48 h post-CLP

 HR (bpm)

455 ± 79

474 ± 39

464 ± 38

0.74

2D Echo

 EF (%)

0.55 ± 0.12

0.6 ± 0.09

0.66 ± 0.05

0.08

 E/A

1.5 ± 0.12

1.49 ± 0.11

1.63 ± 0.32

0.73

 E/e’

23.6 ± 8.04

20.7 ± 6.01

22.27 ± 7.15

0.7

Strain

 CS (%)

−24.4 ± 6.9

−26.3 ± 5.2

−28.3 ± 6.9

0.44

 CSR (%)

−10.75 ± 3.38

−11.3 ± 3.29

−12.44 ± 2.56

0.55

 LS (%)

−17.25 ± 4.72

−22.2 ± 5.8

−24.62 ± 7.12

0.04**

 LSR (%)

−6.8 ± 2.31

−9.52 ± 2.31

−9.54 ± 2.41

0.036**

  1. CLP indicates cecal ligation and puncture, CS global circumferential strain, CSR peak systolic circumferential strain rate, E/A, ratio of peak flow velocity across the mitral annulus during early and late diastole, 2D Echo conventional echocardiography, E/e’ ratio between mitral inflow and mitral annular excursion velocity during early diastole, EF ejection fraction, LS, global longitudinal strain, LSR peak systolic longitudinal strain rate Strain strain echocardiography. **CLP group is significantly different versus sham and control groups