Table 4 MCAT and Wildtype Mice Echocardiographic Metrics at 24 and 48 h post-CLP
CLP (WT) | CLP (MCAT) | Sham (WT) | Sham (MCAT) | p | |
|---|---|---|---|---|---|
24 h post-CLP | |||||
HR (bpm) | 451 ± 69 | 405 ± 71 | 426 ± 78 | 454 ± 79 | 0.64 |
2D Echo | |||||
EF (%) | 58.3 ± 15.5 | 61 ± 10.6 | 61 ± 8 | 52.1 ± 8 | 0.17 |
E/A | 1.34 ± 0.61 | 1.43 ± 0.18 | 1.49 ± 0.22 | 1.37 ± 0.19 | 0.85 |
E/e’ | 16.19 ± 6.9 | 27.9 ± 6.95 | 22.9 ± 4.73 | 20.1 ± 4.06 | 0.01 |
Strain | |||||
CS (%) | −20.9 ± 7.3 | −26.4 ± 8.8 | −25.14 ± 3.18 | −27.5 ± 4.7 | 0.1 |
CSR (%) | −10.32 ± 4.4 | −11.67 ± 7.19 | −10.69 ± 3.27 | −10.2 ± 1.52 | 0.76 |
LS (%) | −15.4 ± 4.1 | −21.5 ± 4.9 | −22.5 ± 3.9 | −22.2 ± 2.8 | 0.01 |
LSR (%) | −6.9 ± 3.75 | −8.9 ± 1.8 | −9.01 ± 2.36 | −10.33 ± 3.74 | 0.01 |
48 h post-CLP | |||||
HR (bpm) | 420 ± 74 | 408 ± 58 | 466 ± 73 | 440 ± 34 | 0.71 |
2D Echo | |||||
EF (%) | 55.2 ± 1.06 | 66 ± 9.7 | 0.61 ± 0.08 | 61.6 ± 6.98 | 0.14 |
E/A | 1.49 ± 0.14 | 1.44 ± 0.08 | 1.49 ± 0.22 | 1.42 ± 0.15 | 0.65 |
E/e’ | 32.41 ± 7.25 | 23.41 ± 7.25 | 22.9 ± 4.73 | 27.15 ± 7.44 | 0.22 |
Strain | |||||
CS (%) | −20.6 ± 7.5 | −29.4 ± 4.7 | −25.14 ± 3.18 | −31.7 ± 3.5 | 0.01 |
CSR (%) | −8.87 ± 3.02 | −13.6 ± 3.07 | −10.69 ± 3.27 | −12.1 ± 1.58 | 0.02 |
LS (%) | −16.5 ± 3.9 | −21.6 ± 4.8 | −22.5 ± 3.9 | −24.15 ± 7.7 | 0.01 |
LSR (%) | −9.06 ± 3.86 | −10.79 ± 2.71 | −9.01 ± 2.36 | −6.69 ± 1.73 | 0.5 |