Skip to main content

Table 1 Score sheet to assess sepsis-induced behaviour changes

From: Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

Rat grimace scale Clinical scoring*
Orbital tightening 0□ 1□ 2□ Reduced activity 0□ 1□ 2□
Nose/cheek flattening 0□ 1□ 2□ Sunken flanks 0□ 1□ 2□
Ear changes 0□ 1□ 2□ Back arching 0□ 1□ 2□
Whisker changes 0□ 1□ 2□ Piloerection 0□ 1□ 2□
     Bloated abdomen 0□ 1□ 2□
     Chromodacryorrhea (= eye discharge) 0□ 1□ 2□
  1. Legend: The score sheet was adapted from [17] and www.ahwla.org.uk. *Six or more points in the clinical scoring lead to a preterm abortion of the experiment by injection of 1 ml phenobarbital i.v.