Intensive Care Medicine Experimental

Table 1 Hemodynamic and resuscitation data in animals with lung over-distension (OD) combined with either high (H_DS) or low (L_DS) dynamic strain. Cardiac output (CO, L/min), mean arterial blood pressure (MAP, mmHg), serum lactate concentration (lactate, mmol/L), norepinephrine (Norepi, mcg/min) and volume of crystalloid delivered (fluids, mL/kg). Data mean ± SD

From: The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model

		BL	T0	T1	T2	T3	T4	T5	T6
CO (L/min)	OD H_DS	4.2 ± 1.4	3.5 ± 1.0	3.2 ± 1.1	3.4 ± 1.1	2.9 ± 0.6	2.8 ± 0.3	2.8 ± 0.5	2.7 ± 0.4
CO (L/min)	OD L_DS	4.9 ± 0.9	2.8 ± 0.8	2.6 ± 0.4	2.3 ± 0.3	2.4 ± 0.4	2.4 ± 0.6	2.7 ± 0.6	2.7 ± 0.6
MAP (mmHg)	OD H_DS ^†	107.5 ± 13.6	83.5 ± 15.6	74.8 ± 5.7	78.3 ± 9.9	80.8 ± 12.2	80.5 ± 11.3	72.5 ± 7.6	60.7 ± 19.1
MAP (mmHg)	OD L_DS ^†	107.3 ± 21.7	83.0 ± 15.8	76.5 ± 7.2	67.3 ± 8.1	74.8 ± 25.7	72.3 ± 10.4	73.8 ± 11.0	70.3 ± 11.3
CVP (mmHg)	OD H_DS ^†	6.5 ± 3.5	10.2 ± 2.1	10.8 ± 2.9	11.5 ± 2.1	11.2 ± 2.4	11.3 ± 2.2	11.0 ± 2.3	11.5 ± 2.9
CVP (mmHg)	OD L_DS ^†	6.2 ± 2.9	11.8 ± 3.1	13.5 ± 2.4	14.2 ± 2.1	13.0 ± 4.6	14.7 ± 4.7	16.8 ± 2.2	15.8 ± 3.8
Lactate (mmol/L)	OD H_DS ^†	2.1 ± 0.6	4.5 ± 1.3	7.2 ± 1.2	8.9 ± 1.1	9.1 ± 1.9	9.4 ± 2.9	9.5 ± 3.1	9.5 ± 2.7
Lactate (mmol/L)	OD L_DS ^†	1.9 ± 0.8	3.7 ± 1.6	5.6 ± 1.5	8.5 ± 1.6	9.7 ± 2.9	10.7 ± 3.1	10.9 ± 3.5	11.4 ± 3.9
Norepi (mcg/min)	OD H_DS ^†	0.0 ± 0.0	0.0 ± 0.0	1.3 ± 2.0	1.6 ± 2.5	4.1 ± 4.3	5.1 ± 5.3	4.8 ± 5.4	2.5 ± 5.5
Norepi (mcg/min)	OD L_DS ^†	0.0 ± 0.0	0.6 ± 1.6	0.6 ± 1.6	0.6 ± 1.6	3.5 ± 4.6	4.1 ± 5.2	4.1 ± 5.2	4.1 ± 5.2
Fluids (mL/h)	OD H_DS ^†	1542 ± 772	2435 ± 890	3211 ± 1578	4749 ± 1932	5636 ± 2233	6191 ± 2338	7200 ± 2592	7949 ± 2653
Fluids (mL/h)	OD L_DS ^†	1351 ± 635	2444 ± 1063	3459 ± 1310	5127 ± 1557	6766 ± 1880	8274 ± 1864	9644 ± 2004	10,901 ± 1993

^†Significant difference within group over time

Back to article page