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Table 2 Properties of the microcirculation before and after the sublingual topical application of acetylcholine and nitroglycerin, as measured using manual video analysis and algorithm-based video analysis

From: Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge

  Native Acetylcholine Nitroglycerin p
TVD (manual) [mm/mm2] 14.81 ± 0.65 15.72 ± 0.49 20.32 ± 0.50a, b <0.0001
Space-time diagram-based venular flow velocity [μm/s] 242 ± 21 358 ± 62 496 ± 22a <0.01
TVD (algorithm-based) [mm/mm2] 18.80 ± 0.61 18.69 ± 0.66 21.06 ± 0.57a, b <0.01
APSI [1] 1.33 ± 0.06 1.43 ± 0.08 1.64 ± 0.08a 0.02
  1. Values are given as mean ± SEM. Pairwise analysis is represented by a, b where p < 0.05 versus nativea, and acetylcholineb. Analysis was performed in n = 41 subjects for TVD (manual), TVD (algorithm-based) and APSI, and in n = 23, n = 27, and n = 14 subjects in the native, acetylcholine, and nitroglycerin condition for space-time diagram-based venular flow velocity, respectively
  2. TVD total vessel density, APSI average perfused speed index