Effect of continuous dialysis on blood pH in acidemic hypercapnic animals with severe acute kidney injury: a randomized experimental study comparing high vs. low bicarbonate affluent

Romano, Thiago Gomes; Azevedo, Luciano Cesar Pontes; Mendes, Pedro Vitale; Costa, Eduardo Leite Vieira; Park, Marcelo

doi:10.1186/s40635-017-0141-6

Intensive Care Medicine Experimental

Table 1 Metabolic variables categorized according to the groups throughout the study

From: Effect of continuous dialysis on blood pH in acidemic hypercapnic animals with severe acute kidney injury: a randomized experimental study comparing high vs. low bicarbonate affluent

Variable	Group	Baseline ^a	1 h^a	2 h	3 h^a	4 h	Last hour	P value
Sodium (mEq/L)	20 mEq/L	133 [131,137]	135 [132,138]	135 [134,141]	133 [138,136]	132 [130,134]	129 [128,131]	0.659^b
Sodium (mEq/L)	40 mEq/L	136 [133,138]	137 [135,139]	136 [133,137]	136 [132,136]	134 [132,136]	131 [119,131]	0.367^c
Chloride (mEq/L)	20 mEq/L	105 [96,107]	107 [102,109]	108 [105,113]	107 [105,108]^f	107 [105,110]	106 [105,109]	0.003^b
Chloride (mEq/L)	40 mEq/L	108 [106,113]	108 [105,112]	105 [103,113]	104 [101,111] ^d	102 [101,112]	101 [95,112]	0.001^c
Potassium (mEq/L)	20 mEq/L	4.4 [3.9,5.3]	5.0 [4,5.6]	4.9 [4.4,5.7]	5.9 [5.3,6.6]	6.4 [5.8,7.4]	6.6 [6.2,7.5]	0.079^b
Potassium (mEq/L)	40 mEq/L	4.4 [3.8, 4.8]	4.2 [3.7,5.3]	4.8 [4.3,6.0]	5.5 [4.6,6.4]	5.2 [4.6,6.5]	5.3 [4.9,7.0]	0.406^c
Calcium (mEq/L)	20 mEq/L	1.22^e [1.12,1.35]	1.22 [0.86,1.27]	1.15 [0.99,1.35]	1.18 [1.15,1.21]^g	1.14 [0.96,1.24]	1.02 [0.93,1.18]	0.226^b
Calcium (mEq/L)	40 mEq/L	1.42 [1.30,2.34]	1.27 [1.16,1.64]	1.17 [1.05,1.85]	1.17 [1.00,1.58]	2.26 [1.83,3.83]	1.07 [0.94,2.89]	0.021^c
Magnesium (mEq/L)	20 mEq/L	2.55 [1.86,2.88	2.41 [1.85,3.37]	–	2.69 [2.20,3.52]	–	2.45 [2.02,3.35]	0.142^b
Magnesium (mEq/L)	40 mEq/L	1.98 [1.53,3.45]	2.3 [1.47,3.8]	–	2.26 [1.83,3.83]	–	2.87 [2.09,4.0]	0.572^c
Glucose (mg/dL)	20 mEq/L	101 [86,174]	111 [98,208]	87 [53,125]	102 [77,199]	100 [63,238]	132 [83,307]	0.892^b
Glucose (mg/dL)	40 mEq/L	114 [92,120]	90 [67,115]	106 [90,136]	103 [92,261]	98 [86,126]	81 [67,220]	0.351^c
Temperature (°C)	20 mEq/L	38 [37.7,38.6]	37.0 [36.6,37.6]^d	37.5 [36.8,37.9]	37.1 [36.7,37.7]^d	37.5 [37.1,37.8]	36.5 [35.7,37.1]	0.011^b
Temperature (°C)	40 mEq/L	37.9 [37.4,38.3]	37.7 [37.4,38]	37.7 [37.1,38.3]	37.7 [37.5,38.5]	37.3 [37.1,38.1]	37.5 [35.8,38.3]	0.445^c
Hemoglobin (g/dL)	20 mEq/L	11.9 [10.9,12.6]	11.7 [10.4,13.0]	12.5 [8.8,13.4]	12.2 [9.8,13.7]	12.5 [9.3,14.4]	11.1 [7.15,12.2]	0.865^b
Hemoglobin (g/dL)	40 mEq/L	11.9 [11.2,13.8]	12.8 [11.2,14.4]	13.3 [12.3,14.0]	12.8 [11.6,13.8]	12.3 [11.5,14.9]	10.8 [8.5,13.7]	0.576^c
Cumulative fluid balance (ml)	20 mEq/L	0 [0,0]	100 [0,225]	200 [150,375]	450 [238,625]^d	450 [238,975]	700 [475,2150]	0.002^b
Cumulative fluid balance (ml)	40 mEq/L	0 [0,0]	150 [0,275]	325 [75,425]	450 [275,600]^d	650 [375,713]	1275 [425,1950]	0.654^c

Data are shown as median [percentile 25th, percentile 75th]
^aOnly the timepoints baseline, 1st, 2nd, and 3rd hour were statistically analyzed
^bMixed model timepoint vs. variable interaction
^cMixed model group vs. variable interaction
^dWilcoxon post hoc analysis, P < 0.05 vs. baseline
^eMann-Whitney post hoc analysis, P < 0.05 vs. group 40
^fMixed model timepoint vs. group interaction P = 0.001. Mann-Whitney post hoc analysis chloride variation from baseline to 3 h P < 0.05 vs. group 40
^gMixed model timepoint vs. group interaction P = 0.046. Mann-Whitney post hoc calcium variation from baseline to 3 h P < 0.05 vs. group 40

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