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Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

Fig. 3

Inflammatory mediators in BALf in controls and after 12 h of mechanical ventilation. Cytokine and chemokine levels in BALf obtained after 12 h of mechanical ventilation. Data are means ± SEM. Facets within the panels represent mechanical ventilation time. Different colors represent different tidal volume groups, and different transparency levels represent different FiO2 groups. 0h no mechanical ventilation time, control group; 12h 12 h of mechanical ventilation, LTV low tidal volumes, HTV high tidal volumes. Cuzick’s P for trend in increasing oxygen levels at 12 h of mechanical ventilation: IL-1β, <0.001; MIP-2, 0.27; IL-6, 0.03; KC, 0.22; IL-10, 0.001; MCP-1, <0.001; TNF-α, 0.001; IFN-γ, 0.001; sRAGE, 0.11; HMGB-1, 0.001. *P for trend <0.05; **P for trend <0.01; ***P for trend <0.001

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