Fig. 2

Urine output (a) and creatinine clearance (b) in 16 anesthetized sheep subjected to left renal ischemia and reperfusion. Renal ischemia was caused by clamping of the renal artery for 90 min. Fifteen minutes prior to the release of the clamp, intravenous infusions with either the organic mononitrites of 1,2-propanediol (PDNO, n = 8) or vehicle (1,2-propanediol + inorganic nitrite, n = 8) were commenced. The infusions continued for 6 h. Data are expressed as mean and SEM. Significant (p < 0.05) differences in response to PDNO compared to vehicle is indicated by an asterisk