Fig. 3
From: The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure
Total left renal blood flow (a) as well as left renal medullar (b) and cortical perfusion (c) as estimated by laser Doppler in 16 anesthetized sheep subjected to left renal ischemia and reperfusion. Renal ischemia was caused by clamping of the left renal artery for 90 min. Fifteen minutes prior to the release of the clamp intravenous infusions of either the organic mononitrites of 1,2-propanediol (PDNO, n = 8) or vehicle (1,2-propanediol + inorganic nitrite, n = 8) were commenced. The infusions continued for 6 h. Data are expressed as mean and SEM. Significant (p < 0.05) differences in response to PDNO compared to vehicle is indicated by an asterisk