From: The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure
Time (h) | 0 | 1.25 | 1.5 | 1.6 | 2.5 | 3.5 | 4.5 | 5.5 | 6.5 | 7.5 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | ||
Cardiac output (L/min) | Vehicle | 8.4 | 0.6 | 7.7 | 0.4 | 7.7 | 0.5 | 7.9 | 0.6 | 7.6 | 1.3 | 9.0 | 0.4 | 8.6 | 0.3 | 8.5 | 0.2 | 8.3 | 0.3 | 7.8 | 0.3 |
PDNO | 7.2 | 0.3 | 6.5 | 0.6 | 6.6 | 0.5 | 6.5 | 0.4 | 8.1 | 0.7 | 8.5 | 0.5 | 8.3 | 0.3 | 8.2 | 0.4 | 8.3 | 0.5 | 7.7 | 0.4 | |
Heart rate (BPM) | Vehicle | 110 | 4 | 103 | 5 | 106 | 5 | 107 | 4 | 109 | 3 | 113 | 2 | 107 | 3 | 109 | 4 | 108 | 4 | 102 | 3 |
PDNO | 108 | 3 | 95 | 8 | 111 | 4 | 114 | 5 | 116 | 5 | 115 | 3 | 109 | 2 | 109 | 5 | 112 | 3 | 108 | 3 | |
Mean arterial blood pressure (mmHg) | Vehicle | 100 | 2 | 107 | 5 | 102 | 4 | 100 | 4 | 96 | 4 | 96 | 4 | 95 | 3 | 93 | 3 | 93 | 4 | 94 | 3 |
PDNO | 95 | 3 | 104 | 6 | 88 | 4 | 82 | 3 | 85 | 2 | 83 | 2 | 82 | 2 | 82 | 2 | 81 | 2 | 83* | 3 |