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Table 1 Hemodynamic parameters

From: The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure

Time (h)

0

1.25

1.5

1.6

2.5

3.5

4.5

5.5

6.5

7.5

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Cardiac output (L/min)

Vehicle

8.4

0.6

7.7

0.4

7.7

0.5

7.9

0.6

7.6

1.3

9.0

0.4

8.6

0.3

8.5

0.2

8.3

0.3

7.8

0.3

PDNO

7.2

0.3

6.5

0.6

6.6

0.5

6.5

0.4

8.1

0.7

8.5

0.5

8.3

0.3

8.2

0.4

8.3

0.5

7.7

0.4

Heart rate (BPM)

Vehicle

110

4

103

5

106

5

107

4

109

3

113

2

107

3

109

4

108

4

102

3

PDNO

108

3

95

8

111

4

114

5

116

5

115

3

109

2

109

5

112

3

108

3

Mean arterial blood pressure (mmHg)

Vehicle

100

2

107

5

102

4

100

4

96

4

96

4

95

3

93

3

93

4

94

3

PDNO

95

3

104

6

88

4

82

3

85

2

83

2

82

2

82

2

81

2

83*

3

  1. Cardiovascular data from 16 anesthetized sheep subjected to left renal ischemia and reperfusion. Renal ischemia was caused by clamping of the left renal artery for 90 min. Fifteen minutes prior to the release of the clamp, intravenous infusions of either the organic mononitrites of 1,2-propanediol (PDNO, n = 8) or vehicle (propanediol + inorganic nitrite, n = 8) was commenced. The infusions continued for 6 h. Data are expressed as mean and SEM.
  2. *Significant (p < 0.05) differences in response to PDNO compared to vehicle at the end of the infusion