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Intensive Care Medicine Experimental
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model

Fig. 1

Overall study design. a Experimental setup 1. P6 rats were injected i.p. with cell-free human Hb. Blood was sampled as indicated by arrows. n = 5–7 at each time point. b Experimental setup 2. P6 rat pups were randomized into four groups, n = 5–11 in each group: (1) i.p. cell-free Hb injection and 24 h hyperoxia (HH), (2) i.p. cell-free Hb injection and 24 h normoxia (HN), (3) i.p. vehicle injection and 24 h hyperoxia (VH), and (4) i.p. vehicle injection and 24 h normoxia (VN). The blood and liver tissue were collected as indicated by arrows

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