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Table 1 miRNA associations with ARDS in discovery cohort, validation cohorts, combined cohorts, and meta-analysis

From: Whole blood microRNA markers are associated with acute respiratory distress syndrome

 

Discovery cohort (n = 156)

Validation cohort (n = 373)

Meta-analysis (n = 529)

MicroRNA

OR (95% CI)

OR (95% CI)

FDR q

OR (95% CI)

p

miR-424

0.52 (0.29–0.93)

0.78 (0.66–0.94)

0.022

0.77 (0.67–0.9)

< 0.001

miR-92a

1.60 (1.11–2.31)

1.75 (1.26–2.43)

0.022

1.69 (1.32–2.17)

< 0.001

miR-181a

1.75 (1.03–2.97)

1.76 (1.21–2.56)

0.037

1.68 (1.26–2.23)

< 0.001

miR-331

1.67 (1.11–2.52)

1.69 (1.12–2.56)

0.097

1.74 (1.29–2.36)

< 0.001

miR-29b

0.66 (0.44–0.99)

0.82 (0.68–0.99)

0.132

0.79 (0.67–0.93)

0.004

miR-1290

0.66 (0.41–1.08)

0.84 (0.72–0.98)

0.097

0.83 (0.73–0.95)

0.006

miR-155

1.57 (1.03–2.38)

1.40 (0.95–2.08)

0.195

1.32 (1.07–1.64)

0.009

miR-148a

0.64 (0.42–0.98)

0.92 (0.7–1.22)

0.511

0.78 (0.62–0.97)

0.023

miR-579

0.57 (0.33–0.97)

0.89 (0.71–1.11)

0.511

0.82 (0.69–0.97)

0.023

miR-1291

0.58 (0.39–0.85)

0.90 (0.73–1.11)

0.511

0.81 (0.68–0.98)

0.027

miR-744*

0.58 (0.38–0.88)

0.89 (0.7–1.13)

0.511

0.82 (0.68–0.99)

0.036

miR-1244

0.64 (0.43–0.95)

0.90 (0.74–1.08)

0.511

0.84 (0.72–0.99)

0.042

miR-486-3p

1.57 (1.02–2.4)

1.12 (0.82–1.53)

0.723

1.28 (1.01–1.63)

0.043

miR-642

1.50 (1.03–2.09)

1.07 (0.88–1.32)

0.723

1.18 (1–1.38)

0.047

miR-340

0.65 (0.44–0.95)

0.93 (0.76–1.15)

0.598

0.87 (0.75–1)

0.057

miR-20a

0.65 (0.43–0.98)

1.02 (0.74–1.41)

0.896

0.87 (0.76–1.01)

0.059

miR-21

0.66 (0.44–0.98)

0.98 (0.76–1.26)

0.723

0.87 (0.74–1.01)

0.067

miR-34a

0.53 (0.31–0.91)

0.95 (0.76–1.2)

0.598

0.85 (0.68–1.05)

0.132

miR-590-3P

0.57 (0.36–0.91)

1.00 (0.87–1.15)

0.896

0.91 (0.81–1.04)

0.165

miR-204

1.57 (1.03–2.38)

0.89 (0.71–1.12)

0.857

1.07 (0.89–1.28)

0.477

miR-493

0.63 (0.39–0.99)

1.16 (0.97–1.39)

0.511

1.03 (0.89–1.2)

0.662

miR-483-5p

0.56 (0.33–0.93)

1.17 (0.98–1.4)

0.481

1 (0.86–1.16)

0.997

  1. Discovery screening based on OR > 1.5 or OR < 0.67. Meta-analysis was conducted based on fixed effect model
  2. OR odds ratio, CI confidence interval, FDR false discovery rate