From: Whole blood microRNA markers are associated with acute respiratory distress syndrome
 | Discovery cohort (n = 156) | Validation cohort (n = 373) | Meta-analysis (n = 529) | ||
---|---|---|---|---|---|
MicroRNA | OR (95% CI) | OR (95% CI) | FDR q | OR (95% CI) | p |
miR-424 | 0.52 (0.29–0.93) | 0.78 (0.66–0.94) | 0.022 | 0.77 (0.67–0.9) | < 0.001 |
miR-92a | 1.60 (1.11–2.31) | 1.75 (1.26–2.43) | 0.022 | 1.69 (1.32–2.17) | < 0.001 |
miR-181a | 1.75 (1.03–2.97) | 1.76 (1.21–2.56) | 0.037 | 1.68 (1.26–2.23) | < 0.001 |
miR-331 | 1.67 (1.11–2.52) | 1.69 (1.12–2.56) | 0.097 | 1.74 (1.29–2.36) | < 0.001 |
miR-29b | 0.66 (0.44–0.99) | 0.82 (0.68–0.99) | 0.132 | 0.79 (0.67–0.93) | 0.004 |
miR-1290 | 0.66 (0.41–1.08) | 0.84 (0.72–0.98) | 0.097 | 0.83 (0.73–0.95) | 0.006 |
miR-155 | 1.57 (1.03–2.38) | 1.40 (0.95–2.08) | 0.195 | 1.32 (1.07–1.64) | 0.009 |
miR-148a | 0.64 (0.42–0.98) | 0.92 (0.7–1.22) | 0.511 | 0.78 (0.62–0.97) | 0.023 |
miR-579 | 0.57 (0.33–0.97) | 0.89 (0.71–1.11) | 0.511 | 0.82 (0.69–0.97) | 0.023 |
miR-1291 | 0.58 (0.39–0.85) | 0.90 (0.73–1.11) | 0.511 | 0.81 (0.68–0.98) | 0.027 |
miR-744* | 0.58 (0.38–0.88) | 0.89 (0.7–1.13) | 0.511 | 0.82 (0.68–0.99) | 0.036 |
miR-1244 | 0.64 (0.43–0.95) | 0.90 (0.74–1.08) | 0.511 | 0.84 (0.72–0.99) | 0.042 |
miR-486-3p | 1.57 (1.02–2.4) | 1.12 (0.82–1.53) | 0.723 | 1.28 (1.01–1.63) | 0.043 |
miR-642 | 1.50 (1.03–2.09) | 1.07 (0.88–1.32) | 0.723 | 1.18 (1–1.38) | 0.047 |
miR-340 | 0.65 (0.44–0.95) | 0.93 (0.76–1.15) | 0.598 | 0.87 (0.75–1) | 0.057 |
miR-20a | 0.65 (0.43–0.98) | 1.02 (0.74–1.41) | 0.896 | 0.87 (0.76–1.01) | 0.059 |
miR-21 | 0.66 (0.44–0.98) | 0.98 (0.76–1.26) | 0.723 | 0.87 (0.74–1.01) | 0.067 |
miR-34a | 0.53 (0.31–0.91) | 0.95 (0.76–1.2) | 0.598 | 0.85 (0.68–1.05) | 0.132 |
miR-590-3P | 0.57 (0.36–0.91) | 1.00 (0.87–1.15) | 0.896 | 0.91 (0.81–1.04) | 0.165 |
miR-204 | 1.57 (1.03–2.38) | 0.89 (0.71–1.12) | 0.857 | 1.07 (0.89–1.28) | 0.477 |
miR-493 | 0.63 (0.39–0.99) | 1.16 (0.97–1.39) | 0.511 | 1.03 (0.89–1.2) | 0.662 |
miR-483-5p | 0.56 (0.33–0.93) | 1.17 (0.98–1.4) | 0.481 | 1 (0.86–1.16) | 0.997 |