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Table 1 miRNA associations with ARDS in discovery cohort, validation cohorts, combined cohorts, and meta-analysis

From: Whole blood microRNA markers are associated with acute respiratory distress syndrome

  Discovery cohort (n = 156) Validation cohort (n = 373) Meta-analysis (n = 529)
MicroRNA OR (95% CI) OR (95% CI) FDR q OR (95% CI) p
miR-424 0.52 (0.29–0.93) 0.78 (0.66–0.94) 0.022 0.77 (0.67–0.9) < 0.001
miR-92a 1.60 (1.11–2.31) 1.75 (1.26–2.43) 0.022 1.69 (1.32–2.17) < 0.001
miR-181a 1.75 (1.03–2.97) 1.76 (1.21–2.56) 0.037 1.68 (1.26–2.23) < 0.001
miR-331 1.67 (1.11–2.52) 1.69 (1.12–2.56) 0.097 1.74 (1.29–2.36) < 0.001
miR-29b 0.66 (0.44–0.99) 0.82 (0.68–0.99) 0.132 0.79 (0.67–0.93) 0.004
miR-1290 0.66 (0.41–1.08) 0.84 (0.72–0.98) 0.097 0.83 (0.73–0.95) 0.006
miR-155 1.57 (1.03–2.38) 1.40 (0.95–2.08) 0.195 1.32 (1.07–1.64) 0.009
miR-148a 0.64 (0.42–0.98) 0.92 (0.7–1.22) 0.511 0.78 (0.62–0.97) 0.023
miR-579 0.57 (0.33–0.97) 0.89 (0.71–1.11) 0.511 0.82 (0.69–0.97) 0.023
miR-1291 0.58 (0.39–0.85) 0.90 (0.73–1.11) 0.511 0.81 (0.68–0.98) 0.027
miR-744* 0.58 (0.38–0.88) 0.89 (0.7–1.13) 0.511 0.82 (0.68–0.99) 0.036
miR-1244 0.64 (0.43–0.95) 0.90 (0.74–1.08) 0.511 0.84 (0.72–0.99) 0.042
miR-486-3p 1.57 (1.02–2.4) 1.12 (0.82–1.53) 0.723 1.28 (1.01–1.63) 0.043
miR-642 1.50 (1.03–2.09) 1.07 (0.88–1.32) 0.723 1.18 (1–1.38) 0.047
miR-340 0.65 (0.44–0.95) 0.93 (0.76–1.15) 0.598 0.87 (0.75–1) 0.057
miR-20a 0.65 (0.43–0.98) 1.02 (0.74–1.41) 0.896 0.87 (0.76–1.01) 0.059
miR-21 0.66 (0.44–0.98) 0.98 (0.76–1.26) 0.723 0.87 (0.74–1.01) 0.067
miR-34a 0.53 (0.31–0.91) 0.95 (0.76–1.2) 0.598 0.85 (0.68–1.05) 0.132
miR-590-3P 0.57 (0.36–0.91) 1.00 (0.87–1.15) 0.896 0.91 (0.81–1.04) 0.165
miR-204 1.57 (1.03–2.38) 0.89 (0.71–1.12) 0.857 1.07 (0.89–1.28) 0.477
miR-493 0.63 (0.39–0.99) 1.16 (0.97–1.39) 0.511 1.03 (0.89–1.2) 0.662
miR-483-5p 0.56 (0.33–0.93) 1.17 (0.98–1.4) 0.481 1 (0.86–1.16) 0.997
  1. Discovery screening based on OR > 1.5 or OR < 0.67. Meta-analysis was conducted based on fixed effect model
  2. OR odds ratio, CI confidence interval, FDR false discovery rate