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Intensive Care Medicine Experimental

Table 4 Diagnostic performance of sepsis/pneumonia model and miRNA combined model for ARDS

From: Whole blood microRNA markers are associated with acute respiratory distress syndrome

Combined cohort (N = 373)

ARDS vs. at-risk controls

AUC (95% CI)

Sensitivity, %

Specificity, %

Accuracy, %

IDI (95% CI)

p

Category-free NRI, % (95% CI)

p

LIPS model

0.708 (0.651–0.766)

64.35

50.81

56.85

Ref.

 

Ref.

 

miR-181a + LIPS

0.719 (0.661–0.776)

65.03

56.82

59.48

1.36 (0.14–2.58)

0.029

15.24 (−6.38–36.87)

0.649

miR-92a + LIPS

0.716 (0.659–0.773)

64.85

56.73

59.37

1.22 (0.09–2.35)

0.034

8.96 (−12.69–30.61)

0.418

miR-424 + LIPS

0.715 (0.659–0.771)

64.78

56.69

59.32

1.43 (0.12–2.74)

0.033

24.24 (2.71–45.76)

0.237

Extended model 1a

0.723 (0.667–0.778)

65.31

56.96

59.67

2.40 (0.72–4.08)

0.005

27.21 (5.72–48.70)

0.014

Extended model 2b

0.728 (0.674–0.783)

65.70

57.14

59.92

3.18 (1.28–5.09)

0.001

36.93 (15.58–58.28)

<0.001

  1. AUC area under the curve, IDI integrated discrimination improvement, NRI net reclassification index, LIPS Lung Injury Prediction Score
  2. aExtend model 1: LIPS + miR-181a + miR-92a + miR-424
  3. bExtend model 2: LIPS + miR-181a + miR-92a + miR-424 + miR-1290 + miR-29b + miR-331
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