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Table 4 Diagnostic performance of sepsis/pneumonia model and miRNA combined model for ARDS

From: Whole blood microRNA markers are associated with acute respiratory distress syndrome

Combined cohort (N = 373) ARDS vs. at-risk controls
AUC (95% CI) Sensitivity, % Specificity, % Accuracy, % IDI (95% CI) p Category-free NRI, % (95% CI) p
LIPS model 0.708 (0.651–0.766) 64.35 50.81 56.85 Ref.   Ref.  
miR-181a + LIPS 0.719 (0.661–0.776) 65.03 56.82 59.48 1.36 (0.14–2.58) 0.029 15.24 (−6.38–36.87) 0.649
miR-92a + LIPS 0.716 (0.659–0.773) 64.85 56.73 59.37 1.22 (0.09–2.35) 0.034 8.96 (−12.69–30.61) 0.418
miR-424 + LIPS 0.715 (0.659–0.771) 64.78 56.69 59.32 1.43 (0.12–2.74) 0.033 24.24 (2.71–45.76) 0.237
Extended model 1a 0.723 (0.667–0.778) 65.31 56.96 59.67 2.40 (0.72–4.08) 0.005 27.21 (5.72–48.70) 0.014
Extended model 2b 0.728 (0.674–0.783) 65.70 57.14 59.92 3.18 (1.28–5.09) 0.001 36.93 (15.58–58.28) <0.001
  1. AUC area under the curve, IDI integrated discrimination improvement, NRI net reclassification index, LIPS Lung Injury Prediction Score
  2. aExtend model 1: LIPS + miR-181a + miR-92a + miR-424
  3. bExtend model 2: LIPS + miR-181a + miR-92a + miR-424 + miR-1290 + miR-29b + miR-331