Table 1 Hemodynamic and laboratory data. Data are presented as median and IQR. The change in hemodynamic and laboratory data within the sepsis and hemorrhage groups at 15 and 60 min after resuscitation were analyzed using one-way ANOVA on ranks (* = P < 0.05 for comparisons with the 10 ml/kg group using the Dunn’s method to correct for multiple comparisons). MAP = mean arterial pressure, PPV = pulse pressure variation, ScvO2 = central venous saturation, Hct = hematocrit, BE = base excess, ∆ = change in respective parameter, ns = no survivors
From: Effect of Ringer’s acetate in different doses on plasma volume in rat models of hypovolemia
Sepsis | Hemorrhage | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Resus. volume ml/kg | 0 (n = 10) | 10 (n = 9) | 30 (n = 10) | 50 (n = 10) | 75 (n = 8) | 100 (n = 8) | 0 (n = 4) | 10 (n = 7) | 30 (n = 8) | 50 (n = 8) | 75 (n = 8) | 100 (n = 8) |
Baseline | ||||||||||||
MAP, mmHg | 99 (73–106) | 98 (89–105) | 95 (86–109) | 102 (81–117) | 116 (93–121) | 93 (79–115) | 88 (71–106) | 99 (85–105) | 95 (84–106) | 89 (78–104) | 83 (65–98) | 85 (76–94) |
PPV, % | 9 (7–11) | 11 (7–15) | 9 (7–13) | 9 (9–13) | 8 (6–9) | 8 (7–15) | 9 (4–16) | 9 (7–11) | 9 (7–11) | 7 (4–11) | 10 (7–11) | 11 (7–13) |
ScvO2, % | 78 (71–80) | 77 (73–80) | 79 (76–82) | 78 (71–84) | 79 (66–81) | 78 (75–83) | 80 (75–83) | 85 (83–88) | 82 (79–85) | 75 (73–79) | 81 (71–84) | 79 (74–83) |
Lactate, mmol/L | 2.1 (1.7–2.2) | 2.2 (1.8–2.4) | 2.1 (1.9–2.5) | 2.3 (2.0–2.6) | 2.0 (1.4–2.2) | 2.1 (2.0–2.7) | 1.9 (1.7–1.9) | 2.4 (1.9–2.6) | 2.0 (1.6–2.4) | 2.2 (1.7–2.5) | 2.5 (2.0–2.9) | 2.1 (1.8–2.7) |
Hct, % | 42 (40–43) | 41 (41–43) | 42 (42–43) | 43 (41–44) | 43 (42–45) | 42 (40–43) | 43 (41–43) | 44 (43–44) | 42 (40–43) | 42 (40–43) | 41 (38–43) | 42 (40–44) |
BE, mEq/L | 4 (3–5) | 4 (3–4) | 5 (3–5) | 4 (3–4) | 4 (3–5) | 4 (3–5) | 5 (4–7) | 4 (3–5) | 5 (4–6) | 6 (3–6) | 5 (4–6) | 5 (3–6) |
Pre- resuscitation | ||||||||||||
MAP, mmHg | 81 (67–92) | 92 (87–108) | 94 (85–98) | 91 (76–96) | 86 (67–100) | 96 (81–109) | 57 (51–66) | 59 (50–80) | 48 (45–51) | 49 (40–55) | 50 (47–51) | 56 (53–60) |
PPV, % | 18 (15–21) | 13 (12–22) | 13 (12–19) | 16 (15–19) | 16 (13–21) | 17 (15–18) | 24 (19–27) | 16 (12–19) | 20 (10–32) | 24 (13–28) | 24 (19–28) | 19 (17–27) |
ScvO2, % | 60 (50–70) | 51 (39–57) | 57 (53–59) | 62 (45–69) | 51 (45–68) | 56 (50–61) | 54 (46–61) | 59 (51–69) | 43 (40–53) | 44 (33–52) | 41 (37–48) | 43 (32–50) |
Lactate, mmol/L | 2.7 (2.6–3.3) | 3.1 (2.7–3.3) | 2.8 (2.2–3.3) | 3.1 (2.8–3.4) | 3.6 (2.8–5.4) | 3.6 (3.2–3.9) | 4.2 (3.2–4.6) | 2.7 (2.4–3.8) | 4.6 (3.8–5.2) | 4.5 (3.8–5.7) | 4.5 (4.1–6.1) | 4.6 (3.9–6.1) |
Hct, % | 46 (41–48) | 46 (43–48) | 46 (43–46) | 48 (44–50) | 46 (41–49) | 49 (42–51) | 30 (27–32) | 26 (25–28) | 28 (26–30) | 28 (26–31) | 28 (27–28) | 29 (27–30) |
BE, mEq/L | −3 (−3– −1) | −3 (−4–-2) | −2 (−4– −1) | −3 (−4– −2) | −5 (−8– −2) | −4 (−4– −1) | −1 (−3–0) | 1 (−2–2) | −1 (−3–0) | −3 (−4– −1) | −2 (−4–1) | −2 (−3–1) |
15 min after resuscitation | ||||||||||||
∆MAP, mmHg | −7 (−19 – −5) | −18 (−36 – −6) | −4 (−8 – −1) | 0 (−8–6)* | −2 (−13–5) | −2 (−9–7) | ns | −7 (−8–0) | 4 (1–6) | 5 (−3–9) | 8 (1–26)* | 2 (−4–14) |
∆PPV, % | −1 (−6–7) | 4 (0–6) | 3 (0–6) | 1 (−10–3) | −4 (−7–6) | −4 (−6–1) | ns | 0 (−3–3) | −4 (−11–2) | −8 (−16 – −2) | −11 (−13– −7)* | −7 (−9 – −2) |
∆ScvO2, % | −9 (−14 – −1) | 1 (−10–7) | −1 (−7–8) | −6 (−13–5) | 6 (−15–15) | 8 (−1–10) | ns | 0 (−4–8) | 9 (0–12) | 9 (1–19) | 13 (8–24) | 19 (−1–26) |
∆Lactate, mmol/L | 0.3 (−0.3–0.6) | −0.2 (−0.5–0.3) | −0.4 (−1.1–0) | −0.7 (−1– −0.3) | −1.1 (−1.9 – −0.6)* | −1.4 (−1.8 – −1.0)* | ns | −0.1 (−0.7–0.2) | −1.0 (−1.6– −0.6) | −1.7 (−2.2– −0.9) | −1.9 (−2.9– −1.2)* | −2.4 (−2.8– −1.1)* |
∆Hct, % | 0 (−1–1) | −3 (−3 – −2) | −4 (−5 – −3) | −5 (−7– −5)* | −6 (−10–0) | −7 (−10 – −3) | ns | −2 (−3 – −1) | −6 (−8 – −5) | −9 (−11– −6) | −11 (−12– −10)* | −12 (−14 – −11)* |
∆BE, mEq/L | −3 (−3 – −1) | −1 (−2– −1) | 1 (0–1) | 2 (1–2)* | 3 (2–5)* | 3 (2–3)* | ns | 0 (−1–1) | 2 (1–4) | 4 (2–5)* | 4 (2–7)* | 4 (2–5)* |
60 min after resuscitation | ||||||||||||
∆MAP, mmHg | −19 (−27–0) | −23 (−53– −16) | −14 (−23– −4) | −14 (−31–0) | −21 (−34 – −6) | −11 (−26– −8) | ns | −8 (−11–2) | 4 (−3–8) | 3 (−3–8) | 10 (2–14)* | 5 (−5–8) |
∆PPV, % | 1 (−3–6) | 4 (−1–7) | 2 (−2–5) | 0 (−5–5) | −2 (−11–5) | −3 (−8–3) | ns | 0 (−4–6) | −1 (−15–7) | −5 (−10–4) | −11 (−14– −6)* | −7 (−17– −3) |
∆ScvO2, % | −19 (−27–12) | −14 (−16– −10) | −10 (−13 – −3) | −16 (−24 – −6) | −6 (−20–7) | −8 (−13–4) | ns | −1 (−13–2) | 3 (−7–7) | 4 (2–6) | 10 (4–18)* | 19 (−2–21)* |
∆Lactate, mmol/L | 1.3 (0.4–2.7) | 0.7 (0.3–3.0) | −0.2 (−0.3–1.2) | 0.8 (−0.1–1.3) | 0 (−0.4–0.6) | −0.8 (−1.0–0)* | ns | 0.5 (−0.6–1.8) | 0.3 (−0.4–1.5) | −0.5 (−0.9–0.8) | −0.4 (−1.4–0.8) | −1.3 (−1.8–2.4) |
∆Hct, % | −1 (−4–0) | −2 (−4– −2) | −5 (−6– −1) | −6 (−6– −4) | −5 (−9– −1) | −8 (−13– −3) | ns | −5 (−6– −3) | −6 (−8– −4) | −9 (−11– −7) | −11 (−12– −10)* | −12 (−13– −10)* |
∆BE, mEq/L | −7 (−8– −5) | −6 (−9– −4) | −3 (−4– −2) | −3 (−4– −2) | −1 (−2–1)* | 0 (−1–1)* | ns | −1 (−4–0) | −1 (−4–2) | 1 (−2–4) | 1 (−2–4) | 2 (−4–3) |
Urine ml/kg/h | 0.4 (0.3–0.5) | 0.5 (0.4–07) | 0.7 (0.6–0.9) | 0.7 (0.5–0.9) | 0.5 (0.3–0.8) | 1.2 (0.8–1.4)* | ns | 0.7 (0.6–0.9) | 0.4 (0.3–0.8) | 0.8 (0.6–1.4) | 1.4 (0.9–1.7) | 1.9 (1.6–2.2)* |