Preliminary experience on the safety and tolerability of mechanical “insufflation-exsufflation” in subjects with artificial airway

Intensive Care Medicine Experimental

Table 2 Baseline and follow-up respiratory and hemodynamic parameters

	Baseline	5′	60″	p
Temperature, °C	37.3 ± 0.82		37.4 ± 0.7	ns
Heart rate, bpm	97.7 ± 14.4	97.1 ± 15.1	97.3 ± 14.2	0.82
Mean blood pressure, mmHg	87 ± 11.9	87.6 ± 14.7	83.6 ± 14.7	0.57
Sat O₂, %	97.38 ± 2.37	98.3 ± 2.2	97 ± 3.4	0.04
pHa	7.43 ± 0.1	7.38 ± 0.1	7.45 ± 0.05	0.17
pHv	7.39 ± 0.1	7.44 ± 0.02	7.42 ± 0.05	0.13
PaO₂, mmHg	105.5 ± 23.9	124 ± 55.5	*143 ± 42.3	0.031
PvO₂, mmHg	54.9 ± 37.4	34.5 ± 4.9	52.4 ± 29	0.67
PaCO₂, mmHg	37.5 ± 12.6	40.5 ± 13.3	35.2 ± 8.2	0.058
PvCO₂, mmHg	45.2 ± 6.7	44.5 ± 3.5	40.2 ± 5.2	0.15
Ventilator mode				0.61
CPAP PC-IMV	20		18
MMV VC-IMV	2		1
Spontaneous respiration	4		7
FiO₂	0.46 ± 0.13	0.45 ± 0.13	0.44 ± 0.1	0.73
PaO₂/FiO₂	239.8 ± 96.8	285.5 ± 140	328.7 ± 104.7	0.14
PvO₂/FiO₂	134.9 ± 114.2	105.9 ± 3.7	132.6 ± 93.9	0.96
Total breath, rate/min	22.1 ± 6.3	23.5 ± 7.1	20.7 ± 5.9	0.10
Minute volume, l/min	10.6 ± 3.6	11.0 ± 3.2	9.6 ± 2.6	0.13
Tidal volume, ml	524.1 ± 106.6	496.3 ± 118.4	493.2 ± 139	0.15
PEEP, mmHg	5.3 ± 2.9	5.3 ± 2.9	4.6 ± 3.2	0.45
Peak inspiratory pressure, cmH₂O	23.6 ± 7.8	24.0 ± 8.1	22.3 ± 5.6	0.17
Plateau pressure, cmH₂O	21.9 ± 5.1	22.5 ± 5.4	20.9 ± 4.4	0.14
Lung compliance
Dynamic	17.7 ± 9.5	16.3 ± 9.4	17.6 ± 9.6	0.4
Static, ml/cmH₂O	18.7 ± 8.8	17.2 ± 9.1	19.1 ± 9.3	0.33
CA tidal volume, ml	1043.6 ± 649.9

Bpm beats per minute, Sat O₂ pulse-oximetry oxygen saturation, pHa arterial pH, pHv venous pH, PaO₂ arterial oxygen partial pressure, PvO₂ venous oxygen partial pressure, PaCO₂ arterial CO2 partial pressure, PvCO₂ venous CO₂ partial pressure, CPAP assisted pressure ventilation, MMV minimal mandatory ventilation, BiPAP controlled pressure mandatory ventilation, IPPV volume-targeted pressure control ventilation, PEEP positive end-expiratory pressure, CA Cough Assist
*Significant difference from baseline