Skip to main content

Table 1 Overview on studies investigating the impact of hyperchloremia on renal function

From: Serum chloride levels in critical illness—the hidden story

Author (year)

Design

Study population

Total study population

Study intervention

Increased incidence of acute kidney injury

Increased need for renal replacement therapy

R

Krajewski ML et al. (2015)

Meta-analysis

Perioperative patients

6253

0.9% saline versus other crystalloid infusates

X

Not investigated

[33]

Shaw B et al. (2012)

Retrospective cohort study

Patients after open abdominal surgery

31,920

0.9% saline versus other crystalloid infusates

X

Not investigated

[35]

Young et al. (2015)

RCT

General ICU population

2278

0.9% saline versus acetate-buffered solute

No difference between the groups

No difference between the groups

[37]

Yunos et al. (2012)

Open label, sequential period study (6 month)

General ICU population

760

Chloride-rich versus chloride-depleted infusion solutes

X

X

[46]

Yunos et al. (2015)a

Open label, sequential period study (1 year)

General ICU population

2994

Chloride-rich versus chloride-depleted infusion solutes

X

X

[57]

Guirgis FW et al. (2015)

Retrospective cohort study

Patients with sepsis/septic shock

95

Chloride-rich versus chloride-depleted infusion solutes

No difference between the groups

No difference between the groups

[59]

Shao M et al. (2016)

Retrospective cohort study

General ICU population

6025

X

Not investigated

[60]

Mattinen E et al. (2016)

Subgroup analysis of RCT

General ICU population

445

X

Not investigated

[4]

McCluskey SA (2013)

Retrospective cohort study

Non-cardiac surgery

22,851

X

Not investigated

[58]

Suetrong B et al. (2016)

Retrospective cohort study

Patients with sepsis/septic shock

240

X

Not investigated

[61]

Zhang Z et al. (2013)

Retrospective cohort study

General ICU population

1221

X

X

[64]

McIlroy D et al. (2017

Open label, sequential period study

Perioperative patients

1136

chloride-rich versus chloride-depleted infusion solutes

No difference between the groups

No difference between the groups

[62]

Sadan O et al. (2017)

Retrospective cohort study

Patients with subarachnoid hemorrhage

1267

X

Not investigated

[65]

Loftus TJ et al. (2017

Retrospective cohort study

Patients undergoing emergent laparatomy

189

0.9% saline versus 3% saline

No difference between the groups

No difference between the groups

[63]

  1. •Sensitivity analysis showed that multiple unknown confounders may have influenced the incidence of AKI and need for RRT in this studySensitivity analysis showed that a multiple unknown confounders may have influenced the incidence of AKI and need for RRT in this study
  2. X = finding was found