From: Serum chloride levels in critical illness—the hidden story
Author (year) | Design | Study population | Total study population | Study intervention | Increased incidence of acute kidney injury | Increased need for renal replacement therapy | R |
---|---|---|---|---|---|---|---|
Krajewski ML et al. (2015) | Meta-analysis | Perioperative patients | 6253 | 0.9% saline versus other crystalloid infusates | X | Not investigated | [33] |
Shaw B et al. (2012) | Retrospective cohort study | Patients after open abdominal surgery | 31,920 | 0.9% saline versus other crystalloid infusates | X | Not investigated | [35] |
Young et al. (2015) | RCT | General ICU population | 2278 | 0.9% saline versus acetate-buffered solute | No difference between the groups | No difference between the groups | [37] |
Yunos et al. (2012) | Open label, sequential period study (6 month) | General ICU population | 760 | Chloride-rich versus chloride-depleted infusion solutes | X | X | [46] |
Yunos et al. (2015)a | Open label, sequential period study (1 year) | General ICU population | 2994 | Chloride-rich versus chloride-depleted infusion solutes | X | X | [57] |
Guirgis FW et al. (2015) | Retrospective cohort study | Patients with sepsis/septic shock | 95 | Chloride-rich versus chloride-depleted infusion solutes | No difference between the groups | No difference between the groups | [59] |
Shao M et al. (2016) | Retrospective cohort study | General ICU population | 6025 | – | X | Not investigated | [60] |
Mattinen E et al. (2016) | Subgroup analysis of RCT | General ICU population | 445 | – | X | Not investigated | [4] |
McCluskey SA (2013) | Retrospective cohort study | Non-cardiac surgery | 22,851 | – | X | Not investigated | [58] |
Suetrong B et al. (2016) | Retrospective cohort study | Patients with sepsis/septic shock | 240 | – | X | Not investigated | [61] |
Zhang Z et al. (2013) | Retrospective cohort study | General ICU population | 1221 | – | X | X | [64] |
McIlroy D et al. (2017 | Open label, sequential period study | Perioperative patients | 1136 | chloride-rich versus chloride-depleted infusion solutes | No difference between the groups | No difference between the groups | [62] |
Sadan O et al. (2017) | Retrospective cohort study | Patients with subarachnoid hemorrhage | 1267 | – | X | Not investigated | [65] |
Loftus TJ et al. (2017 | Retrospective cohort study | Patients undergoing emergent laparatomy | 189 | 0.9% saline versus 3% saline | No difference between the groups | No difference between the groups | [63] |